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Combinations of compounds for the treatment or prevention of skin diseases

A compound, dermatological technology, applied in the direction of skin diseases, drug combinations, anhydride/acid/halide active ingredients, etc., can solve problems such as irritation or intolerance

Inactive Publication Date: 2015-08-19
GALDERMA RES & DEV SNC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] These treatments have unpleasant side effects for patients, such as irritation or intolerance
Additionally, no existing treatment is effective in treating and / or preventing all symptoms associated with rosacea

Method used

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  • Combinations of compounds for the treatment or prevention of skin diseases
  • Combinations of compounds for the treatment or prevention of skin diseases
  • Combinations of compounds for the treatment or prevention of skin diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] Embodiment 1: Brimonidine 0.20% / Azelaic acid 15% solution

[0113] Element

Embodiment 2

[0114] Embodiment 2: Brimonidine 0.15% / Azelaic Acid 10% Solution

[0115] Element

Embodiment 3

[0116] Embodiment 3: Brimonidine 0.18% / Azelaic Acid 10% Gel

[0117] Element

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PUM

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Abstract

The invention relates to a combination of compounds for treating skin diseases and particularly rosacea and ocular rosacea. It is the combination of a compound selected from azelaic acid and salts thereof with a compound of the alpha-1 or alpha-2 adrenergic receptor agonist family. The invention also relates to a product in the form of a kit containing: (a) a first composition comprising a compound selected from azelaic acid and salts thereof, and (b) a second composition different from the first one and comprising a compound of the alpha-1 or alpha-2 adrenergic receptor agonist family, as a combination product for application thereof as a medicament for treating and / or preventing skin diseases and in particular rosacea and ocular rosacea, wherein said first and second compositions can be applied simultaneously, separately or with a time delay.

Description

technical field [0001] The present invention relates to combinations of compounds useful in the treatment of human skin diseases, especially rosacea and ocular rosacea. Background technique [0002] Rosacea is a common chronic, progressive inflammatory dermatitis associated with vasodilation. It mainly affects the middle part of the face and is characterized by redness or hot flashes of the face, facial erythema, papules, pustules, telangiectasias and sometimes ocular lesions, called ocular rosacea. In severe cases, especially in men, the soft tissues of the nose swell and produce a bulbous swelling called hypertrophic rosacea. [0003] Rosacea usually occurs between the ages of 25 and 70, and it is more common in people with fair skin. Although the disease is generally more severe in men, it more particularly affects women. Rosacea is chronic and lasts for years in cycles of exacerbations and remissions. [0004] The pathogenesis of rosacea is poorly understood. Many f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K31/00A61K31/20A61K31/498A61P17/00A61P27/02
CPCA61K31/498A61K31/194A61K45/06A61K31/00A61K31/20A61K9/0014A61K9/0048A61P17/00A61P27/02A61K2300/00
Inventor J-P·沙皮伊E·艾特
Owner GALDERMA RES & DEV SNC
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