Functional polymer containing amino aryl ethylene and preparation method of functional polymer

Abstract

The invention relates to a functional polymer containing amino aryl ethylene and a preparation method of the functional polymer. The preparation method comprises the following steps of: initiating free radical polymerization of a monomer acetamino aryl ethylene in an alcohol-water solvent by using a method for initiating solution polymerization by utilizing free radicals; then, adjusting the molecular weight of the polymer by using lauryl mercaptan; and separating in an alcohol-water system to obtain the functional polymer containing amino aryl ethylene, wherein the molecular weight of the functional polymer is within a certain range. The polymer can be dissolved or most of the polymer can be dissolved in the hot alcohol-water system; and the polymer can be used for substituting for highly-cancerogenic o-chloroaniline or other micromolecular aniline derivatives to prepare a key intermediate 2-methyl-4-amino-5-aminomethyl pyrimidine of vitamin B1. The functional polymer containing amino aryl ethylene can be recycled after being filtered; the polymer can be used for completely substituting for o-chloroaniline to prepare vitamin B1; and the preparation method is simple and convenient to operate and high in yield.

Description

technical field [0001] The invention relates to an aminoaromatic vinyl functional polymer and a preparation method thereof, belonging to the technical field of vinyl functional polymers. Background technique [0002] As an important basic nutrient, vitamin B1 has many important physiological functions. The structural formula of vitamin B1 is as follows: [0003] [0004] In the past ten years, the preparation of vitamin B1 and its derivatives has attracted much attention. Among them, 2-methyl-4-amino-5-aminomethylpyrimidine is the key intermediate commonly used in the preparation of vitamin B1. And the three kinds of routes about the synthesis of 2-methyl-4-amino-5-aminomethylpyrimidine all have various disadvantages: such as the cyanopyrimidine route needs to use a large amount of ethyl acetimide hydrochloride (1.8 to 2 Equivalent), the raw material and malononitrile are expensive, which is not conducive to the reduction of product cost; the reaction steps of the formy...

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Problems solved by technology

And the three kinds of routes about the synthesis of 2-methyl-4-amino-5-aminomethylpyrimidine all have various disadvantages: such as the cyanopyrimidine route needs to use a large amount of ethyl acetimide hydrochloride (1.8 to 2 Equivalent), the raw material and malononitrile are expensive, which is not conducive to the reduction of product cost; the reaction steps of the formyl pyrimidine route are complicated, the reaction cycle is long, and an autoclave (about 50 kg pressure) is used for hydrogenation reaction, which is difficult to implement industrially; The formylaminopyrimidine route uses 3-aminopropionitrile as the starting raw material, although the raw material of this route is cheap and easy to get, the reaction conditions of each step are relatively mild, and the yield is higher, which is conducive to product cost control

But this route has fatal disadvantages: it uses highly carcinogenic o-chloroaniline, which requires high operating environment and is not conducive to environmental protection; and despite steam distillation and multiple recrystallizations, it is still difficult to remove trace amounts of o-chloroaniline in the final product vitamin B1. Chloroaniline

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