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Lignin compounds and their uses

A technology of lignin and compounds, applied in the direction of active ingredients of hydroxyl compounds, organic chemistry, ether separation/purification, etc.

Inactive Publication Date: 2016-03-09
TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But except magnolol and honokiol, other active ingredients in magnolia bark that have inhibitory effect on HIV-1 protease have not been reported yet.

Method used

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  • Lignin compounds and their uses
  • Lignin compounds and their uses
  • Lignin compounds and their uses

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0031] Embodiment 1 The method for separating and purifying HIV-1 protease inhibitor from Magnolia officinalis

[0032] 1) Extraction and extraction of Magnolia officinalis medicinal materials

[0033] Take 15 kg of Magnolia officinalis as raw material, extract with 95% ethanol at 60°C, add 5 liters of 95% ethanol to each kg of Magnolia officinalis, and extract three times, and the obtained extract is filtered through gauze and then concentrated to obtain the extract. paste, the extract was dissolved into a suspension with a small amount of water, and three times the volume of ethyl acetate was added to extract three times to obtain the ethyl acetate extract, and the n-butanol extract was obtained in the same way, and the remaining components were concentrated to dryness into the water phase.

[0034] 2) Test the inhibitory activity of ethyl acetate and n-butanol extract to HIV-1 protease

[0035] Test the inhibitory effect of ethyl acetate extract and n-butanol extract to HI...

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Abstract

The invention provides a lignin compound and functions thereof. The structural formula of the lignin compound is as shown in a general formula (I), wherein R1 is from an alkyl group of C1-C4 or an alkyl acyl group of the C1-C4, and R2 is from hydrogen or the alkyl group of the C1-C4 or the alkyl acyl group of the C1-C4. The lignin compound can effectively inhibit activity of human immunodeficiency virus-1 (HIV-1) protease, and inhibitory activity IC 50 of a compound 5-allyl-5'-(1-ethyoxyl-2-hydroxy-propyl group)-biphenyl-2,2'-diphenol on the HIV-1 protease is 200uM.

Description

technical field [0001] The invention belongs to the technical field of medicinal chemistry, in particular, the invention relates to a lignin compound and its application in preparing medicines for treating and preventing AIDS. Background technique [0002] Acquired Immunodeficiency Syndrome (Acquired Immune Deficiency Syndrome, abbreviated as AIDS), also known as AIDS, is an infectious disease caused by Human Immunodeficiency Virus (HIV). HIV virus is a virus that can attack the human immune system. It targets the most important T4 lymphocytes in the human immune system, engulfs and destroys T4 lymphocytes in large quantities, thereby destroying the human immune system and eventually causing the immune system to collapse. It makes the human body fall ill due to the loss of resistance to various diseases, resulting in various infections or tumors, and finally leads to death. [0003] The harm of AIDS has swept the world, and the spread is very rapid. In 1984, there were les...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C43/178C07C41/34A61K31/075A61K31/05A61K31/085A61P31/18
Inventor 陈卫强杨诚郭宇周红刚张坛杰唐延婷丁宏兰李金楠冯金磊
Owner TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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