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Gastrodin injection preparation and preparation method

A gastrodin injection and preparation technology, applied in the field of medicine, can solve the problems of increasing the risk of clinical use, adverse reactions, patient pain, etc., and achieve the effects of facilitating drug absorption, reducing body stimulation, and simplifying prescriptions

Inactive Publication Date: 2013-06-05
YANGZHOU ZHONGBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When gastrodin is used clinically as an injection, the existing routes of administration are intramuscular injection or intravenous infusion, and visible foreign matter is the focus of small-volume injection inspection. Patients bring pain, and some even form granulation and various adverse reactions, which increase the risk of clinical use. Therefore, how to avoid the appearance of endogenous visible foreign bodies in the preparation of gastrodin injection is a key factor at this stage

Method used

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  • Gastrodin injection preparation and preparation method
  • Gastrodin injection preparation and preparation method
  • Gastrodin injection preparation and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0026] A Gastrodia elata injection preparation comprises the following components by weight percentage:

[0027]

[0028] The preparation method is as follows:

[0029] (1) Weigh 70% of the water for injection of the formula and cool to 30-40°C;

[0030] (2) Dissolve the metal ion complexing agent disodium calcium ethylenediaminetetraacetate in the formulated amount in the cooled water for injection in step (1);

[0031] (3) Weigh the formula amount of gastrodin and dissolve it in the solution obtained in step (2). After the dissolution is complete, add the formula amount of stabilizer sodium chloride;

[0032] (4) Use disodium hydrogen phosphate-sodium dihydrogen phosphate buffer solution to adjust the pH value of the solution obtained in step (3) within the range of 5.0 to 7.0;

[0033] (5) Add 0.1wt% activated carbon to the solution obtained in step (4), stir and let it stand for adsorption for 15 minutes, filter for decarburization, supplement the amount of water for ...

Embodiment 2

[0035] A Gastrodia elata injection preparation comprises the following components by weight percentage:

[0036]

[0037]

[0038] The preparation method is as follows:

[0039] (1) Weigh 70% of the water for injection of the formula and cool to 30-40°C;

[0040] (2) Dissolve the metal ion complexing agent disodium calcium ethylenediaminetetraacetate in the formulated amount in the cooled water for injection in step (1);

[0041] (3) Weigh the formula amount of gastrodin and dissolve it in the solution obtained in step (2). After the dissolution is complete, add the formula amount of stabilizer sodium chloride;

[0042] (4) Use disodium hydrogen phosphate-sodium dihydrogen phosphate buffer solution to adjust the pH value of the solution obtained in step (3) within the range of 5.0 to 7.0;

[0043] (5) Add 0.1wt% activated carbon to the solution obtained in step (4), stir and let it stand for adsorption for 15 minutes, filter for decarburization, supplement the amount o...

Embodiment 3

[0045] A Gastrodia elata injection preparation comprises the following components by weight percentage:

[0046]

[0047] The preparation method is as follows:

[0048] (1) Weigh 70% of the water for injection of the formula and cool to 30-40°C;

[0049] (2) Dissolve the metal ion complexing agent disodium ethylenediaminetetraacetate in the formulated amount in the cooled water for injection in step (1);

[0050] (3) Weigh the formula amount of gastrodin and dissolve it in the solution obtained in step (2). After the dissolution is complete, add the formula amount of stabilizer sodium sulfite;

[0051] (4) Use acetic acid-sodium acetate buffer solution to adjust the pH value of the solution obtained in step (3) to be in the range of 5.0 to 7.0;

[0052] (5) Add 0.1wt% activated carbon to the solution obtained in step (4), stir and let it stand for adsorption for 15 minutes, filter for decarburization, supplement the amount of water for injection, fill with nitrogen, potti...

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Abstract

The invention discloses a gastrodin injection preparation, which comprises the following components by weight: 5-10% of gastrodin, 0.01-0.1% of metal ion complexing agent, 0.6-1.2% of stabilizing agent, 1-2.5% of buffer and the balance of injection water. The invention also provides a preparation method of the gastrodin injection preparation. The gastrodin injection of the present invention can effectively stop the addition of visible foreign matter during a placing process of the gastrodin injection, the defective index of the visible foreign matter in a solution is reduced, the white point and white block precipitation are not generated, the expectation effect can be reached, thereby the treatment effect of gastrodin can be fully performed. The gastrodin injection preparation has the advantages of simple prescription, good stability, high clear degree, safe clinical usage, small adverse reaction and convenient industrial large batch production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a gastrodin injection preparation and a preparation method thereof. Background technique [0002] Gastrodia elata is one of the precious Chinese medicinal materials in my country, and it is the dry tuber of Gastrodia elata of the orchidaceae plant. Widely produced in Yunnan, Guizhou, Sichuan, Shaanxi and other places. As early as 2,000 years ago, "Shen Nong's Materia Medica" recorded that Gastrodia elata has the functions of calming the liver and relieving wind, dredging collaterals and relieving pain. Modern pharmacological research proves that Gastrodia elata has sedative, anticonvulsant, analgesic, anti-inflammatory effects, anti-aging, improvement of learning and memory, different effects on high-level nerve center and cardiovascular, and has little toxicity. Studies have shown that gastrodin also has a nootropic and anti-aging effect, and foreign studies have ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/7034A61K47/18A61P39/06A61P25/00A61P25/22
Inventor 葛海涛唐俊
Owner YANGZHOU ZHONGBAO PHARMA
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