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Novel method for extracting astragaloside from radix astragali

A technology of astragalus saponins and astragalus, applied in the field of natural organic chemistry, can solve the problems of low extraction purity and low extraction rate, and achieve the effects of high extraction purity, large adsorption capacity and obvious separation effect.

Inactive Publication Date: 2013-05-22
DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of conventional techniques such as relatively low extraction rate and low extraction purity, and provide a method for enriching and purifying astragalosides in Astragalus membranaceus by utilizing water vapor reflux extraction and membrane separation technology and macroporous adsorption resin coupling method

Method used

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Examples

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Effect test

Embodiment 1

[0018] Example 1: A method for enriching and purifying astragalosides in Astragalus membranaceus by using steam reflux extraction and membrane separation technology and macroporous adsorption resin coupling method, the steps are as follows:

[0019] (1) After crushing 100 g of dried Radix Astragali, pass through a 60-mesh sieve, add purified water with a volume that is 10 times the crushed volume of Radix Astragali, and carry out steam reflux extraction, extracting twice, and the extraction time is 2 hours;

[0020] (2) merging the astragalus extracts treated in (1), and microfiltration, the pore size ranges from 0.1 to 1 micron, and the pressure is controlled at 0.1 MPa to obtain the filtrate;

[0021] (3) The filtrate through microfiltration is then subjected to ultrafiltration, the ultrafiltration molecular weight cut-off is 3000-300000, the temperature is controlled at 20°C, and the pressure is controlled at 0.1MPa to obtain the crude extract of astragaloside;

[0022] (4)...

Embodiment example 2

[0027] Implementation case 2: A method for enriching and purifying astragalosides in Astragalus membranaceus by using water vapor reflux extraction and membrane separation technology and macroporous adsorption resin coupling method, the steps are as follows:

[0028] (1) After crushing 100 g of dried Radix Astragali, pass through a 40-mesh sieve, add purified water with a volume that is 15 times the crushed volume of Radix Astragali, carry out steam reflux extraction, extract twice, and the extraction time is 2 hours;

[0029] (2) Merge the Radix Astragali extracts treated in (1), and microfiltration, the pore size ranges from 0.1 to 1 micron, and the pressure is controlled at 0.2MPa to obtain the filtrate;

[0030] (3) Pass the microfiltration filtrate through an ultra-station again, the molecular weight cut-off of ultrafiltration is 3,000-300,000, the temperature is controlled at 30° C., and the pressure is controlled at 0.2 MPa to obtain the crude extract of astragaloside; ...

Embodiment example 3

[0036] Implementation case 3: A method for enriching and purifying astragalosides in Astragalus membranaceus by using water vapor reflux extraction and membrane separation technology and macroporous adsorption resin coupling method, the steps are as follows:

[0037] (1) After crushing 100 g of dried Radix Astragali, pass through an 80-mesh sieve, add purified water whose volume is 20 times the crushed volume of Radix Astragali, and carry out steam reflux extraction, extracting 3 times, and the extraction time is 2 hours;

[0038] (2) Merge the Radix Astragali extracts treated in (1), and microfiltration, the pore size ranges from 0.1 to 1 micron, and the pressure is controlled at 0.2MPa to obtain the filtrate;

[0039] (3) The filtrate through microfiltration is then subjected to ultrafiltration, the ultrafiltration molecular weight cut-off is 3000-300000, the temperature is controlled at 40°C, and the pressure is controlled at 0.2MPa to obtain the crude extract of astragalosi...

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Abstract

The invention aims at overcoming the defects of relatively low extraction rate, low extraction purity and the like in the prior art, and provides a method for enriching and purifying astragaloside contained in radix astragali by utilizing a water vapor reflux extraction and membrane separation technology and a macroporous adsorption resin coupling method. The method provided by the invention can be used for separating and purifying the astragaloside by adopting the water vapor reflux extraction and membrane separation technology and the macroporous adsorption resin coupling method, has the advantages of complete astragaloside extraction without pollution, good separation effect, high purity and good adsorption selectivity, fast absorption, fast resolution, large adsorption capacity, obvious separation effect and high extraction purity of macroporous resin and can obtain the astragaloside semi-finished products with content more than 30% and astragaloside finished products with content more than 95% and overcome the defects of relatively low conventional extraction rate and low extraction purity.

Description

Technical field: [0001] The invention belongs to the field of natural organic chemistry, and relates to a method for purifying astragaloside, in particular to a method for enriching and purifying astragaloside in astragalus by utilizing water vapor reflux extraction and membrane separation technology and macroporous adsorption resin coupling method. Background technique: [0002] Astragalus: Also known as Astragalus, it is a general term for plants and Chinese medicinal materials. The plant Astragalus is produced in Inner Mongolia, Shanxi, Gansu, Heilongjiang and other places, and is a national third-level protected plant. Astragalus membranaceus, a traditional Chinese medicinal material, is the root of Astragalus mongolica and Astragalus membranaceus, which have the functions of invigorating qi and strengthening the surface, diuresis and swelling, detoxifying and discharging pus, and promoting muscle growth. The medicinal use of Astragalus has a history of more than 2,000 ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61P37/02A61P7/06A61P13/12B01D11/02B01D15/08
Inventor 万莉姚德坤张亚红姚德利
Owner DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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