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Adapalene gel

A gel, selected technology, applied in the field of adapalene topical pharmaceutical composition, can solve problems such as death, blood calcium reduction, convulsions and the like

Active Publication Date: 2013-05-15
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, it should be pointed out that patients with lead poisoning who should be treated with edetate calcium and sodium, especially children, may cause serious decrease in blood calcium, convulsions and even death due to misuse of edetate disodium

Method used

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  • Adapalene gel
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1

[0027] Adapalene 1g, Propylene Glycol 80g, Poloxamer 188 10g, Carbomer 940 15g, Sodium Hydroxide 1.5g, Edetate Calcium Sodium 0.1g, Methylparaben 1g, Phenoxyethanol 3g Water to 1000g

[0028] Preparation method

[0029] 1) Take 80% of the prescribed amount of purified water, add calcium sodium edetate to dissolve, and obtain liquid (1)

[0030] 2) Mix and stir the prescribed amount of propylene glycol, phenoxyethanol, and methyl p-hydroxybenzoate to obtain liquid (2)

[0031] 3) Fully infiltrate the prescribed amount of carbomer solution (2) and add it to the slow solution (1), stir until it is fully dispersed and then let stand until it swells fully. get liquid (3)

[0032] 4) Take 10% of the prescribed amount of purified water, add the prescribed amount of boloxamer and adapalene and mix until the adapalene is completely dispersed to obtain a solution (4).

[0033] 5) Mix liquid (4) and liquid (3) and stir evenly to obtain liquid (5).

[0034] 6) Dissolve the prescribed...

Embodiment 1-2

[0036] According to the recipe and process of Example 1-1, the amount of calcium sodium edetate was changed to 0.25g.

Embodiment 1-3

[0038] According to the recipe and process of Example 1-1, the amount of calcium sodium edetate was changed to 1 g.

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PUM

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Abstract

The invention provides an adapalene gel. The adapalene gel comprises adapalene serving as an active ingredient, water, humectant, surface active agent, carbopol and neutralizer, wherein the water, humectant, surface active agent, polyacrylic acid and neutralizer are adopted as the auxiliary materials; and the adapalene gel is characterized by comprising sodium calcium edetate.

Description

technical field [0001] The present invention relates to adapalene pharmaceutical composition for external use. Background technique [0002] Adapalene, (Adapalene, CAS: 106685-40-9) is a new retinol drug, a naphthoic acid derivative of a fully aromatic acid, belonging to the third generation of retinoic acid drugs, with a wide range of pharmacology Activities, including anti-inflammatory, anti-proliferative, etc. [0003] adapalene [0004] Adapalene topical preparations are mainly gels, such as the adapalene gel (trade name: Daphne) produced by Galderma Pharmaceutical Company of France, whose prescription contains 0.1g adapalene per 10g, and the auxiliary materials are propylene glycol, Carbomer, Poloxamer 182, Disodium Edetate, Methylparaben, Phenoxyethanol, Sodium Hydroxide, Purified Water. . In this prescription, edetate disodium is added as a metal ion chelating agent. According to the regulations of the State Food and Drug Administration, the packaging and packa...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/192A61K47/18A61K47/32A61P17/10
Inventor 孙亮赵琳陈松
Owner TIANJIN JINYAO GRP
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