Therapeutic agent, composition including said agent, implantable device and process for the treatment of cervical cancer and/or for the prevention of the formation of neoplasms in correspondence of the cervix in a human female genital system

A technology of reproductive system and therapeutic agent, applied in the direction of organic active ingredients, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve problems such as toxic side effects

Inactive Publication Date: 2013-05-08
IST NAZ PER LO STUDIO E LA CURA DEI TUMORI
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

This solution has also caused toxic side effects and requires the use of relatively high doses of therapeutic agents

Method used

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  • Therapeutic agent, composition including said agent, implantable device and process for the treatment of cervical cancer and/or for the prevention of the formation of neoplasms in correspondence of the cervix in a human female genital system
  • Therapeutic agent, composition including said agent, implantable device and process for the treatment of cervical cancer and/or for the prevention of the formation of neoplasms in correspondence of the cervix in a human female genital system
  • Therapeutic agent, composition including said agent, implantable device and process for the treatment of cervical cancer and/or for the prevention of the formation of neoplasms in correspondence of the cervix in a human female genital system

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Embodiment

[0150] Administration of cetuximab using the device 1 is particularly beneficial in the treatment of the above-mentioned pathological conditions.

[0151] VEGFR overexpression is associated with poor prognosis in several solid tumors including cervical cancer, where higher VEGF levels are associated with higher stages and increased risk of lymph node metastasis. In addition, emerging data indicate that HPV directly stimulates VEGF production by upregulating the E6 oncoprotein. Bevacizumab delivered using Device 1 can be used to treat advanced cervical cancer; Bevacizumab delivered using Device 1 can be used alone and / or in combination with chemotherapy (cisplatin, paclitaxel, and topotecan), available in Device 1 or intravenous injection delivers the chemotherapy. Optionally, radiation therapy can be added.

[0152] Device 1 may be used for local delivery of taxol or cisplatin. Local delivery of taxol and / or cisplatin can be effectively combined with IV delivery of the same...

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Abstract

A medical composition including a chemotherapeutic medication or a targeted therapy medication is used in a human female patient for the treatment of a disease selected in the group comprising cervical cancer, cervical intraepithelial neoplasia (CIN), human papillomavirus (HPV) infection of the female genital system; the chemotherapeutic agent or targeted therapy medication is locally delivered directly to cervix of a female genital system by an implanted medical device including a stem to be implanted in the cervix. The stem has a drug carrying layer including the medical composition. A process for the treatment of the above diseases is also disclosed.

Description

technical field [0001] The present invention relates to therapeutic agents, compositions comprising said therapeutic agents, implantable devices and methods for the treatment of cervical cancer and / or for the prevention of tumor formation in the cervix of the human female reproductive system. Background technique [0002] It is well known that cervical cancer (carcinoma of the uterine cervix, CUC) is the second most common gynecological tumor in industrialized countries and the leading cause of death among female populations in developing countries. [0003] Despite the possibility of effective secondary prevention (pap test), cervical neoplasia is still the cause of approximately 4800 deaths per year in the United States, while approximately 3700 new cases and 1700 deaths are reported per year in Italy. [0004] Surgery is the treatment of choice in the earliest stages of the disease, ie when the tumor is confined to the cervix. In these stages, postoperative treatment may...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61M31/00
CPCA61K31/4965A61K9/0036A61M31/002A61K31/337A61L27/00A61K2039/505A61K33/24A61L27/54A61K31/517
Inventor 弗兰塞斯科·拉斯帕列西
Owner IST NAZ PER LO STUDIO E LA CURA DEI TUMORI
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