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Method for reducing ash content of notoginseng polysaccharide

A technology of ash content and Panax notoginseng polysaccharide, which is applied in the field of extraction and removal of impurities of biological products, can solve the problem of not considering the influence of heavy metals and ash in Panax notoginseng extract, not considering the content of Panax notoginseng polysaccharide and ash, resin column regeneration and activation Difficulties and other problems, to achieve the effect of reducing the content of ash such as heavy metals, reducing the content of ash, and reducing the pressure

Inactive Publication Date: 2013-05-08
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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  • Abstract
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  • Application Information

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Problems solved by technology

However, there are relatively few patents and documents on the production process of Panax notoginseng polysaccharide, and the extraction process is relatively simple, basically without considering the influence of heavy metals and ash in the Panax notoginseng extract
Chinese patent application number is 200810233772.4, "Preparation method and application of cosmetics containing Panax notoginseng polysaccharide" provides a method of extracting Panax notoginseng crude polysaccharide with water, but does not consider the content and ash content of Panax notoginseng polysaccharide; the application number is 01108493.6" "Extraction and separation method of notoginseng polysaccharide" provides a method for extracting notoginseng polysaccharides. The waste residue after extracting notoginseng saponins is extracted with water, and then precipitated with ethanol to obtain notoginseng polysaccharides. It also does not consider the heavy metals and The impact of ash and impurities; the application number is 201210058942.6 "A Preparation Method and Application of Physiologically Active Panax notoginseng Polysaccharide" provides a method for extracting and refining Panax notoginseng polysaccharide, taking the Panax notoginseng waste residue after extracting Panax notoginseng saponins Extract with water, remove impurities by resin adsorption, decolorize with activated carbon after ultrafiltration, and dry to obtain Panax notoginseng polysaccharide, but the ash content of the obtained Panax notoginseng polysaccharide is more than 12%, which is also difficult to meet the production and application requirements of pharmaceutical, food and cosmetic raw materials. And the extract is adsorbed by the resin column to remove impurities. Since the water extract contains a large amount of protein, inorganic impurities and heavy metals, it is difficult to regenerate and activate the resin column, and it is also troublesome to clean the ultrafiltration membrane, which can easily cause filter membrane blockage. Activated carbon can adsorb Panax notoginseng polysaccharide, reduce the yield of panax notoginseng polysaccharide
The content of notoginseng polysaccharide extracted by the above-mentioned prior art is generally between 20-30%, and the heavy metal ash content is also as high as 20-30%, which is difficult to meet the requirements of medicines, health products and cosmetics

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  • Method for reducing ash content of notoginseng polysaccharide

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Embodiment 1

[0018] Weigh 100g of notoginseng residue dried after extracting notoginseng saponins, add 1000mL distilled water to soak for 6 hours, heat to 100°C to extract for 2 hours, filter, collect the filtrate, add 700mL distilled water to the filter residue, heat to 100°C to extract for 2 hours, filter , collect the filtrate and merge with the first extraction filtrate, add 600mL distilled water to the filter residue and heat to 100°C for extraction for 2 hours, filter, collect the filtrate and merge the previous second extraction filtrate, cool the filtrate and centrifuge to obtain the extract, heat the extract to 50 °C decompression and vacuum concentration to 600mL, heated to 60°C, stirred and added ZTC clarifier prepared with a volume of 2% volume, left to clarify for 12 hours, and then centrifugally filtered to obtain a centrifugal clarified liquid, which was added to a 732-type cation exchange resin on the column, and washed with water until there is no sugar reaction, collect th...

Embodiment 2

[0020] Weigh 100g of notoginseng residue raw material after extraction of notoginseng saponins, soak in 1000mL distilled aqueous solution for 12 hours, heat to 92°C for extraction for 2 hours, filter through 2 layers of gauze, collect the filtrate, add 1000mL to the filter residue and heat to 92°C for extraction After 1.5 hours, filter through gauze, add the filtrate to the first extract, add 800 mL of distilled water to the filter residue and heat to 92°C for extraction for 1 hour, filter through gauze, incorporate the filtrate into the previous extract, and discard the filter residue. Leave the extract to cool, and centrifugally filter to get 3000mL of filtered extract, heat to 70°C, stir and add 101 fruit juice clarifier solution with 8% volume, keep warm and stir for 30min, cool naturally, place for clarification for 12 hours, centrifugally filter, collect centrifugal clarifier liquid, added to the 734-type cation exchange resin column, and washed with water until the sugar...

Embodiment 3

[0022]Weigh 100 g of the raw material after extraction of notoginseng saponins, add 2000 mL of distilled water and soak for 24 hours, heat to 92°C for extraction for 3 hours, filter through heated 2 layers of gauze, collect the filtrate, add 1500 mL of distilled water to the filter residue, heat to 92°C for 2 hours, multiply Heat 2 layers of gauze for filtration, combine the filtrate with the first extract, add 1000 mL of distilled water to the filter residue and heat to 92°C for extraction for 1 hour, filter with 2 layers of gauze, combine the filtrate with the previous two extracts, and discard the filter residue. Heat the extract to 60°C, depressurize to -0.08MPa, collect to 500mL, heat to 60°C, stir and add 5g chitosan powder, heat and stir for 30 minutes, leave to cool for 10 hours, centrifugal filter, centrifugal filter clarified liquid is added On the D001 cationic resin column, elute with distilled water, collect the eluting solution, recover the water under reduced pre...

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Abstract

The invention discloses a method for reducing ash content of notoginseng polysaccharide and improving yield and purity thereof. The method regards notoginseng as a raw material and obtains the notoginseng polysaccharide of low ash by exacting, clearing, deionizing, sedimenting and drying, which is capable of effectively reducing the ash of notoginseng polysaccharide to below 1%, improving the yield for more than 5% and improving the content for more than 70%. The method for reducing ash content of notoginseng polysaccharide disclosed by the invention has the advantages of greatly reducing the content of ash and heavy metal, preventing the ion exchange resin from poisoning, reducing pressure of ion exchange resin, improving efficiency of ion exchange resin, improving product quality and providing advantageous security for production and application of notoginseng polysaccharide.

Description

Technical field: [0001] The invention belongs to the technical field of extracting and removing impurities from biological products, and in particular relates to a method for reducing the ash content of Panax notoginseng polysaccharide. Background technique: [0002] Panax notoginseng is a famous Chinese medicinal material in my country. In addition to being directly used as a traditional Chinese medicinal material, it is also the source of raw materials for extracting notoginseng saponins. It has formed a large-scale production and utilization. The medicines produced with notoginseng saponins as raw materials include notoginsenoside tablets and capsules , injection, dripping pills, etc., such as Xuesaitong, Qilisheng, Qishengjing, etc. The raw material of notoginseng after extraction of notoginseng saponins also contains a large amount of notoginseng polysaccharides. Notoginseng polysaccharides have many uses and can be used as health care products, medicines, cosmetics, etc...

Claims

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Application Information

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IPC IPC(8): C08B37/00
Inventor 刘锡葵肖建青
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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