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Simulated tendinous sheath film and preparation method thereof

A technology of tendon sheath and synovium, which is applied in the field of bionic materials, can solve the problems of poor mechanical strength and stability, difficulty in ensuring long-term retention and continuous effect, and short retention time of sodium hyaluronate, so as to improve curative effect and prevent exogenous healing , Improve the effect of postoperative function

Inactive Publication Date: 2013-05-01
范存义 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the short retention time of sodium hyaluronate in the body, poor mechanical strength and stability, it is difficult to ensure its long-term retention in the body to achieve the continuous effect of anti-adhesion

Method used

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  • Simulated tendinous sheath film and preparation method thereof
  • Simulated tendinous sheath film and preparation method thereof
  • Simulated tendinous sheath film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Weigh 2.4g of PLC and dissolve it in 7g of THF solution to obtain a fiber layer solution.

[0051] Weigh 0.1g HA to be completely dissolved in 1.5g water to form a hyaluronic acid gel, and weigh 2.4g PLC to dissolve in 7g tetrahydrofuran solution; add hyaluronic acid gel to the tetrahydrofuran solution of PCL, use a vortex mixer to mix, and then add 2.5 g of hexafluoroisopropanol were mixed using a vortex mixer to prepare a synovial layer solution (HA accounted for 4% of the total amount of HA and PLC).

[0052] The fiber layer solution and the synovium layer solution were spun by electrospinning in succession to obtain a double-layer biomimetic tendon sheath membrane (PCL-HA4%). The electrospinning process parameters were as follows: voltage 30kV, flow rate 0.04mL / min, the distance between the receiving table and the spinneret is 15cm.

Embodiment 2

[0054] Weigh 2.3g PLC and dissolve it in 7g tetrahydrofuran solution to obtain a fiber layer solution.

[0055] Weigh 0.2g HA to be completely dissolved in 3g water to form hyaluronic acid gel, and weigh 2.3g PLC to dissolve in 7g tetrahydrofuran solution; add hyaluronic acid gel to PCL tetrahydrofuran solution, use a vortex mixer to mix, and then add 2.5 g of hexafluoroisopropanol and mix using a vortex mixer to prepare a synovial layer solution (HA accounted for 8% of the total amount of HA and PLC).

[0056] The fiber layer solution and the synovium layer solution were spun by electrospinning in succession to obtain a biomimetic tendon sheath membrane (PCL-HA8%) with a double-layer structure. The electrospinning process parameters were as follows: voltage 30kV, flow rate 0.04mL / min, the distance between the receiving table and the spinneret is 15cm.

Embodiment 3

[0058] Weigh 2.2g PLC and dissolve it in 7g tetrahydrofuran solution to prepare fiber layer solution.

[0059] Weigh 0.3g HA and dissolve it completely in 4.5g water to form a hyaluronic acid gel, and weigh 2.3g PLC and dissolve it in 7g tetrahydrofuran solution; add hyaluronic acid gel to the tetrahydrofuran solution of PCL, use a vortex mixer to mix, and then add 2.5 g of hexafluoroisopropanol were mixed using a vortex mixer to prepare a synovial layer solution (HA accounted for 12% of the total amount of HA and PLC).

[0060] The fiber layer solution and the synovium layer solution were spun by electrospinning in succession to obtain a biomimetic tendon sheath membrane (PCL-HA12%) with a double-layer structure. Among them, the electrospinning process parameter conditions were: voltage 30kV, flow rate 0.04mL / min, the distance between the receiving table and the spinneret is 15cm.

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Abstract

The invention provides a simulated tendinous sheath film which adopts a double-layered structure. The simulated tendinous sheath film comprises a fibrous layer and a synovial layer, wherein the fibrous layer is made of degradable high polymer material, and does not contain hyaluronic acid (HA) or metal salt; and the synovial layer is made of degradable high polymer material, and contains hyaluronic acid (HA) or metal salt. The synovial layer contains the hyaluronic acid (HA) or metal salt, thereby realizing the controlled release of HA or the metal salt, simulating the function of secreting HA by the tendinous sheath inner layer, providing a long-acting lubrication action environment for tendon, promoting the endogenous healing of the tendon, improving the tendon healing quality, and improving the postoperation function of the tendon; and the fibrous layer mainly serves as a physical barrier, thereby reducing the paratenon adhesion, and preventing exogenous healing. Moreover, the biodegradable high polymer material can be automatically degraded, is non-toxic, free from immunogenicity, and good in biocompatibility, improves the curative effect, and reduces the side effect.

Description

technical field [0001] The invention relates to a bionic material, in particular to a bionic tendon sheath and a preparation method thereof. Background technique [0002] Tendon adhesion is a common clinical disease. Due to the lack of effective adhesion prevention and treatment measures, the treatment often falls into a vicious cycle of "adhesion-release-re-adhesion", which seriously affects the limb function of patients. Placing anti-adhesion membranes between the tendon and surrounding tissue has some effect in reducing tendon adhesions, but they do not have the function of promoting tendon healing and sliding. In addition, due to material or structural reasons, the wrapped tendon can only function as a physical barrier, and possible rejection and interference with tendon healing will seriously affect the recovery of tendon function. Therefore, it is of great significance to find a suitable anti-adhesion film material and structure, load anti-adhesion drugs, promote tend...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/18
Inventor 范存义刘珅崔文国
Owner 范存义
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