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Chimeric momp antigen, method and use

A composition and technology of Chlamydia trachomatis, applied in the direction of Chlamydia antigen components, chemical instruments and methods, antibacterial drugs, etc., can solve the problems of non-functionality and inability to provide effects, achieve flexible administration routes, improve immune effects, easy to produce effects

Active Publication Date: 2015-06-24
SPIXIA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, the isolated epitope may not be functional in a synthetic context and thus not provide the desired effect

Method used

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  • Chimeric momp antigen, method and use
  • Chimeric momp antigen, method and use
  • Chimeric momp antigen, method and use

Examples

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Embodiment Construction

[0058] In order for those skilled in the art to be able to implement the present invention, several embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. However, this invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. The examples do not limit the invention, but the invention is only limited by the appended claims. Furthermore, the terminology used in the detailed description of the specific embodiments shown in the drawings is not intended to be limiting of the invention.

[0059] The following description focuses on an embodiment of the invention applicable to a polypeptide for generating a protective immune response against Chlamydia trachomatis, and in particular...

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Abstract

The present invention regards polypeptides capable of eliciting an immunological response that is protective against Chlamydia trachomatis. The polypeptide comprises a first amino acid sequence which has at least 90% homology with the amino acid sequence according to SEQ ID NO: 1 and a second amino acid sequence which has at least 90% homology with the amino acid sequence according to SEQ ID NO: 2. Furthermore, production of these polypeptides and pharmaceutical compositions comprising them are also provided.

Description

technical field [0001] The present invention relates generally to the field of polypeptides capable of inducing a protective immune response (reaction) against Chlamydia trachomatis. More specifically, the invention relates to the production of these polypeptides and to pharmaceutical compositions comprising them. Background technique [0002] The major outer membrane protein (MOMP), one of the proteins forming the outer membrane complex of Chlamydia trachomatis, is known to induce two T-cell responses and neutralize antibodies against Chlamydia infection in mammals such as humans. Schematic overview of MOMP proteins in figure 1 Shown in, adapted from Findlay HE, McClafferty H & Ashley RH (2005), Surface expression, single-channel analysis and membrane topology of recombinant Chlamydia trachomatis major outer membrane protein). BMC Microbiology 5,5 is a paper elucidating the topology of MOMP proteins. exist figure 1 In, A represents the cell membrane and B represents th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/295A61K39/118
CPCA61K39/118C07K14/295C07K2319/40A61P31/04
Inventor S·安德森·斯特里德
Owner SPIXIA BIOTECH
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