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Emulsifiable paste containing tea polyphenol extract and application of emulsifiable paste

A technology of extracts and tea polyphenols, applied in the field of skin barrier protection agents, can solve problems such as unfavorable treatment, decreased skin barrier function, and lack of in-depth research on skin barrier repair

Inactive Publication Date: 2013-04-17
HANGZHOU THIRD HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The topical drugs for eczema are mostly hormonal drugs, but long-term use will lead to a significant decline in the barrier function of the skin, which is not conducive to the treatment
At present, there is no clear drug that can promote the restoration of the skin barrier by regulating the expression of AQP3, and the previous research on tea polyphenols has mostly focused on the anti-oxidation and anti-tumor effects, and there is no in-depth research on the repair of the skin barrier

Method used

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  • Emulsifiable paste containing tea polyphenol extract and application of emulsifiable paste
  • Emulsifiable paste containing tea polyphenol extract and application of emulsifiable paste
  • Emulsifiable paste containing tea polyphenol extract and application of emulsifiable paste

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 simple base emulsifiable cream (mass proportion):

[0030] Triethanolamine 0.2%

[0031] Stearic acid 5.0%

[0032] Glyceryl monostearate 4.0%

[0033] White Vaseline 4.0%

[0034] Glycerin 12.0%

[0035] Liquid paraffin 19.0%

[0036] Add water to 100.0%.

[0037] The simple base cream is prepared according to the formula ratio as follows: take stearic acid, glyceryl monostearate, white vaseline, and liquid paraffin in the oil phase and heat to 70-80°C in a water bath; Ethanolamine is added to purified water and heated to 70-80°C to dissolve; when the temperature of the oil phase and the water phase are the same, slowly add the oil phase to the water phase, and stir while adding to make it emulsified.

Embodiment 2

[0038] Example 2 Preparation of cream containing tea polyphenol extract, i.e. skin barrier protector

[0039] 1wt% tea polyphenol cream (mass ratio):

[0040] Tea Polyphenol Extract 1.0%

[0041] Triethanolamine 0.2%

[0042] Stearic acid 5.0%

[0043] Glyceryl monostearate 4.0%

[0044] White Vaseline 4.0%

[0045] Glycerin 12.0%

[0046] Liquid paraffin 19.0%

[0047] Add water to 100.0%

[0048]Prepare the cream containing 1wt% tea polyphenol extract according to the formula ratio as follows: take the oil phase components stearic acid, glyceryl monostearate, white vaseline, and liquid paraffin in a water bath and heat to 70-80°C; Take glycerin and triethanolamine from the water phase, add purified water and heat to 70-80°C to dissolve; when the temperature of the two phases is the same, slowly add the oil phase to the water phase, and stir while adding to make it emulsified. When the temperature drops below 60°C, add a solution of tea polyphenol extract dissolved in...

Embodiment 3

[0049] Example 3 3wt% tea polyphenol cream (mass ratio):

[0050] Tea Polyphenol Extract 3.0%

[0051] Triethanolamine 0.2%

[0052] Stearic acid 5.0%

[0053] Glyceryl monostearate 4.0%

[0054] White Vaseline 4.0%

[0055] Glycerin 12.0%

[0056] Liquid paraffin 19.0%

[0057] Add water to 100.0%.

[0058] Prepare the cream containing 3wt% tea polyphenol extract according to the formula ratio as follows: take the oil phase components stearic acid, glyceryl monostearate, white vaseline, and liquid paraffin in a water bath and heat to 70-80°C; Phase components Glycerin and triethanolamine are added to purified water and heated to 70-80°C to dissolve; when the temperature of the two phases is the same, slowly add the oil phase to the water phase, and stir while adding to make it emulsified. When the temperature drops below 60°C, add a solution of tea polyphenol extract dissolved in an appropriate amount of purified water (preferably add 10ml of purified water per gram of...

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Abstract

The invention discloses an emulsifiable paste containing tea polyphenol extract and application of the emulsifiable paste. Each gram of emulsifiable paste is composed of the following raw materials by mass percent: 1-3% of tea polyphenol extract, 0.2-0.4% of triethanolamine, 5.0-10.0% of stearic acid, 3.0-5.0% of monoglyceride, 4.0-6.0% of albolene, 8.0-12.0% of glycerol, 15.0-20.0% of liquid paraffin and the balance of water. The emulsifiable paste containing the tea polyphenol extract provided by the invention is capable of increasing the moisture content of the skin and reducing transepidermal water loss and giving play to the barrier effect of the skin; the emulsifiable paste plays an important role in preventing light aging phenomenons such as dry skin caused by UVB (Ultraviolet B); and clinically, the emulsifiable paste can be used for assisting to treat dryness and desquamation phenomenons of skin diseases such as eczema and psoriasis.

Description

(1) Technical field [0001] The invention relates to a skin barrier protection agent, in particular to a cream containing tea polyphenol extract and its preparation method, as well as its application in the preparation of the skin barrier protection agent. (2) Background technology [0002] The skin barrier is of great significance to maintain the normal physiological functions of the human body, and its structural basis is mainly the stratum corneum, epidermal lipids, natural moisturizing factors, etc. The main function of the skin barrier is to prevent water loss and external environmental aggression, and the water content of the stratum corneum is the key to maintaining the integrity of the skin barrier. Under physiological conditions, the water content of the stratum corneum accounts for about 20-35% of the epidermis. If the water content is less than 10%, dryness and desquamation will occur, which will accelerate skin aging and skin diseases. The skin barrier function o...

Claims

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Application Information

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IPC IPC(8): A61K8/97A61Q19/00A61K8/34A61K8/36A61K8/41A61K8/37A61K8/92
Inventor 宋秀祖许爱娥
Owner HANGZHOU THIRD HOSPITAL
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