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Medicine for treating post-dural puncture headache (PDPHA)

A post-headache and drug technology, applied in the field of drugs for the treatment of post-dural puncture headache, can solve the problems of cerebral circulation autoregulation dysfunction, conflict, different pathogenesis and other problems

Inactive Publication Date: 2013-04-03
李刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above treatment schemes have the following defects in the treatment of postdural puncture headache: ①The pathogenesis of postdural puncture headache is different from that of angioneurotic headache. Postdural puncture headache is mostly related to the loss of cerebrospinal fluid and the dysfunction of cerebral circulation autoregulation; ②Using qi-activating and blood-activating drugs, Xifeng Zhispasm drugs, in some cases, conflicts with the operation of the primary disease; ③Headache after dural puncture is related to the dysfunction of the automatic regulation of cerebral circulation, which has not been paid attention to by Western medicine and traditional Chinese medicine. at this point

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1, the weight ratio of raw materials: Usnea 10g, Shixiang 8g, Scutellaria chinensis 8g, Aescin chinensis 6g, papaya 6g, pangolin 8g, Cimicifuga 6g, cassia twig 3g, stone gallbladder 3g.

Embodiment 2

[0027] Example 2, the weight ratio of raw materials: Usnea 20g, Shixiang 15g, Scutellaria chinensis 15g, Aescin 10g, Chinese papaya 10g, pangolin 15g, Cimicifuga 10g, cassia twig 6g, stone gall bladder 6g.

Embodiment 3

[0028] Example 3, raw material drug weight ratio: Usnea 15g, Shixiang 10g, Scutellaria 10g, Aescin 8g, Chinese papaya 8g, pangolin 10g, Cimicifuga 8g, cassia twig 5g, stone gallbladder 5g.

[0029] During use, decoct the Chinese medicine Usnea of ​​the present invention, shixiangfeng, sarcophagus, aescin, papaya, pangolin, Cimicifuga, stone gallbladder, and cassia twig with water, merge the filtrate, and take it in the morning and evening. Or make dosage forms such as oral liquid and use.

[0030] The effective combination and coordination of the above drugs can effectively achieve the purpose of treating headache after dural puncture with less side effects. The above results are fully proved by the clinical data, and the relevant data are as follows, wherein the drug used in the study is the weight ratio of the bulk drug in Example 3.

[0031] 1 Objects and methods.

[0032] 1.1 Objects: 42 patients with headache after dural puncture from January 2008 to September 2011. All...

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Abstract

The invention discloses a medicine for treating post-dural puncture headache (PDPHA) to solve the problem of treatment of PDPHA. The medicine is characterized by being prepared from the following raw materials in parts by weight: 10-20 parts of Chinese usnea, 8-15 parts of mosla chinensis maxim, 8-15 parts of herba sarcandrae, 6-10 parts of paris polyphylla, 6-10 parts of pawpaw, 8-15 parts of pangolin scales, 6-10 parts of largetrifoliolious bugbane rhizome, 3-6 parts of cassia twig and 3-6 parts of stone ball. Clinical experiments prove that the medicine has the characteristics of good curative effect on PDPHA and higher safety, and deserves clinical application and promotion.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a medicine for treating headache after dural puncture. Background technique [0002] Postdural puncture headache (PDPHA) is the most common complication of dural puncture and an important problem for anesthesiologists. A study on obstetric anesthesia conducted by the American Society of Anesthesiologists in 1999 showed that among 434 obstetric anesthesia patients, 71% planned to undergo cesarean section and 29% underwent vaginal delivery. Although maternal death was the most common complication in this series, headache was the third most common complication at 15%. Compared with rare events such as brain injury or brain death, the incidence of PDPHA is so high that it has become a very headache for anesthesiologists. Patients with PDPHA are very painful, which seriously affects postoperative recovery. [0003] It is generally believed that the pathogenesis of PDPHA ...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61P25/00A61P9/10
Inventor 李刚崔丽芳
Owner 李刚
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