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Preparation method and application of tablet for regulating menstruation and activating blood

A technology of regulating menstruation, activating blood circulation, and making Corydalis Corydalis with vinegar, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, antineoplastic drugs, etc. It can solve the problems of large dosage for patients, rough process, and many impurities, and achieve the effect of reducing dosage

Inactive Publication Date: 2013-03-27
HEILONGJIANG UNIV OF CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Tiaojing Huoxue Tablets. However, the methods of powdering and decocting in water are rough and outdated, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. , seriously affecting the clinical application of this product

Method used

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  • Preparation method and application of tablet for regulating menstruation and activating blood

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 20g Muxiang, 20g Chuanxiong, 20g Corydalis made with vinegar, 60g Angelica, 40g Rehmannia glutinosa, 40g Chishao, 30g Safflower, 30g Aegya, 30g Atractylodes Rhizoma, 60g Salvia, 60g Cyperus cyperi, 10g Evodia rutaecarpa made from licorice water, Orchid 60g, Caulis Spatholobus 60g, Cuscuta 80g, woody, chuanxiong, vinegar Corydalis, angelica, safflower, join in the CO2 supercritical extractor, ethanol is used as entrainer, and the volume percentage of entrainer accounting for the total extraction solvent is 4%, extraction pressure 15MPa, temperature 30℃, CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained for later use; the rest of the traditional Chinese medicine is taken, pulverized, added with 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 400W, and the extraction is performed twice. Combine the extracts for 4 minutes each time, concent...

Embodiment 2

[0028] Take 20g Muxiang, 20g Chuanxiong, 20g Corydalis made with vinegar, 60g Angelica, 40g Rehmannia glutinosa, 40g Chishao, 30g Safflower, 30g Aegya, 30g Atractylodes Rhizoma, 60g Salvia, 60g Cyperus cyperi, 10g Evodia rutaecarpa made from licorice water, Add 60g of orchid, 60g of Caulis Spatholobus, 80g of dodder, add woody fragrance, Chuanxiong, vinegar Corydalis, angelica, and safflower to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction, with an extraction power of 600W, and extracted twice. 8 minutes each time, combine the e...

Embodiment 3

[0031] Take 20g Muxiang, 20g Chuanxiong, 20g Corydalis made with vinegar, 60g Angelica, 40g Rehmannia glutinosa, 40g Chishao, 30g Safflower, 30g Aegya, 30g Atractylodes Rhizoma, 60g Salvia, 60g Cyperus cyperi, 10g Evodia rutaecarpa made from licorice water, Add 60g of orchid, 60g of Caulis Spatholobus, 80g of dodder, add woody fragrance, Chuanxiong, vinegar Corydalis, angelica, and safflower to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction is performed twice. Combine the extracts for 6...

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Abstract

The invention provides a preparation method of a tablet for regulating menstruation and activating blood. The tablet is prepared by using 20g of costustoot, 20g of szechuan lovage rhizome, 20g of corydalis yanhusuo processed with rice vinegar, 60g of Chinese angelica, 40g of cooked rehmannia, 40g of red paeony root, 30g of safflower, 30g of combined spicebush root, 30g of Largehead atractylodes rhizome, 60g of danshen root, 60g of processed cyperus, 10g of medcinal evodia fruit processed with licorice water, 60g of hiraute shiny bugleweed herb, 60g of suberect spatholobus stems and 80g of Chinese dodder seeds as bulk drugs and adopting supercritical extraction and microwave-assisted extraction modes. By adopting the preparation method, the ferulic acid content is greatly improved; and the invention also provides application of the tablet for regulating menstruation and activating blood in preparation of drugs for inhibiting cell proliferation of mice mast cell carcinoma P815.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of a tablet for regulating menstruation and activating blood. Background technique [0002] Tiaojing Huoxue Tablets are recorded in the standard WS3-B-0614-91 of the Ministry of Health, consisting of 20g Muxiang, 20g Chuanxiong, 20g Corydalis made of vinegar, 60g Angelica, 40g Rehmannia glutinosa, 40g Radix Paeoniae Rubra, 30g safflower, 30g Wuyao, 30g Atractylodes macrocephala , Salvia miltiorrhiza 60g, Rhizoma cyperi 60g, Evodia rutaecarpa licorice water 10g, Eupatorium 60g, Caulis Spatholobus 60g, and Cuscuta 80g are made as raw materials, which can regulate menstruation and blood circulation, promote qi and relieve pain. For irregular menstruation, menstrual pain. [0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Tiaojin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61P35/00
Inventor 不公告发明人
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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