Application of liquiritin in preparing escherichia coli fluoroquinolone efflux pump inhibitor

Abstract

The invention discloses an application of liquiritin in preparing an escherichia coli fluoroquinolone efflux pump inhibitor. Research results indicate that, the liquiritin can obviously reduce the minimal inhibitory concentration of fluoroquinolone of drug-resistant escherichia coli (fluoroquinolone active efflux phenotype and acrA gene high expression strain), obviously increase drug accumulation concentration in a thallus, and obviously reduce expression quantity of an efflux pump gene acrA, so that susceptibility of the drug-resistant escherichia coli to the fluoroquinolone is increased, usage amounts of drugs are reduced, treatment cost is reduced, and food safety problems such as drug residues are decreased. Simultaneously, the liquiritin is a natural compound existing in plants, has no side effects such as teratogenesis and carcinogenesis, and is safe and nontoxic. The invention not only broadens application fields of the liquiritin and improves market value of the liquiritin, but also provides an efficient and safe bacteria efflux pump inhibitor for anti-infective therapy.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a new pharmaceutical application of liquiritin. Background technique [0002] With the widespread and inappropriate use of antibacterial drugs, various types of drug-resistant bacteria continue to emerge, and anti-infection treatment is facing severe challenges. According to literature reports, the resistance rate of pathogenic bacteria to most quinolones has reached more than 50%, and the resistance rate of individual drugs in some areas has even reached 100%. The problem of bacterial resistance has reached a very serious level. For the aquaculture industry, bacterial drug resistance seriously reduces the therapeutic effect of antibacterial drugs, increases the cost of treatment, increases the risk of aquaculture, and significantly reduces the efficiency of aquaculture. In order to enhance the therapeutic effect of drugs, some farms have begun to increase the dose of antibacterial drugs, w...

AI Technical Summary

Problems solved by technology

The feasibility analysis shows that the complete cessation of the use of existing antibacterial drugs in our country will cause a devastating blow to the aquaculture industry, and the research and development of new drugs requires a lot of manpower, material resources, financial resources and a long cycle, and the new drugs developed may also be very expensive. Therefore, it is difficult for these two methods to fundamentally solve the increasingly serious problem of current bacterial drug resistance.

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