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Method for rapidly extracting pueraria isoflavones from pueraria waste

A technology of pueraria isoflavones and waste materials, which is applied in the directions of pharmaceutical formulations, plant raw materials, and medical preparations containing active ingredients, etc., can solve the problems of long extraction time, large solvent consumption, low extraction rate, etc., and achieves short extraction time. , Improve the speed and extraction rate, and ensure the effect of product quality

Inactive Publication Date: 2013-03-13
HEFEI UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the existing problems of large solvent consumption, long extraction time and relatively low extraction rate in extracting kudzu root isoflavones from kudzu root waste materials, the present invention provides a high yield and less solvent-used kudzu root waste material extraction method. Method for Rapidly Extracting Pueraria Isoflavones

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The specific operation steps for rapid extraction of Pueraria isoflavones from Pueraria radiata waste are as follows:

[0014] (1) Take 200 grams of kudzu root waste that has been crushed and passed through a 20-mesh sieve, and put it into a 1L pressure tank (supercritical CO can be borrowed) 2 Extraction tank), open the inlet valve to inject liquid CO 2 , make the pressure in the tank reach 7MPa and keep it for 30 minutes, open the outlet valve to quickly release the pressure to normal pressure, and take out the extruded material;

[0015] (2) Put the extruded material into the extraction tank, and add 900ml of 60% ethanol, after heating up to 50°C, stir and supplement with ultrasonic extraction, the extraction time is 15 minutes, and then the liquid residue is separated. Then add 700 milliliters of 60% ethanol to the slag, and extract for the second time for 10 minutes; combine the extracts, filter and centrifuge to obtain the clear solution;

[0016] (3) Concentrat...

Embodiment 2

[0018] The specific operation steps for rapid extraction of Pueraria isoflavones from Pueraria radiata waste are as follows:

[0019] (1) Take 200 grams of kudzu root waste that has been crushed and passed through a 20-mesh sieve, put it into a 1L pressure tank (a supercritical CO2 extraction tank can be borrowed), open the intake valve and inject liquid CO 2 , make the pressure in the tank reach 7.5MPa and keep it for 15 minutes, open the outlet valve to quickly release the pressure to normal pressure, and take out the extruded material;

[0020] (2) Put the extruded material into the extraction tank, and add 900ml of 60% ethanol, after heating up to 55°C, stir and supplement with ultrasonic extraction, the extraction time is 20 minutes, and then the liquid residue is separated. Then add 700 milliliters of 60% ethanol to the slag, and carry out the second extraction for 10 minutes; combine the extracts, filter and centrifuge to obtain the clear liquid;

[0021] (3) Concentra...

Embodiment 3

[0023] The specific operation steps for rapid extraction of Pueraria isoflavones from Pueraria radiata waste are as follows:

[0024] (1) Take 200 grams of kudzu root waste that has been crushed and passed through a 20-mesh sieve, and put it into a 1L pressure tank (supercritical CO can be borrowed) 2 Extraction tank), open the inlet valve to inject liquid CO 2 , make the pressure in the tank reach 7.5MPa and keep it for 15 minutes, open the outlet valve to quickly release the pressure to normal pressure, and take out the extruded material;

[0025] (2) Put the extruded material into the extraction tank, and add 900ml of 60% ethanol, after heating up to 53°C, stir and supplement with ultrasonic extraction, the extraction time is 18 minutes, and then the liquid residue is separated. Then add 700 milliliters of 60% ethanol to the slag, and carry out the second extraction for 10 minutes; combine the extracts, filter and centrifuge to obtain the clear liquid;

[0026] (3) Concen...

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PUM

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Abstract

The invention relates to a method for rapidly extracting pueraria isoflavones from pueraria waste. The method specifically comprises the following steps of: (1) crushing the pueraria waste, puffing by adopting liquid state CO2; (2) secondarily extracting the puffed pueraria waste by adopting supersonic waves, mixing extracting solutions of two times, and obtaining clear liquid through filtering and centrifuging; and (3) carrying out vacuum concentration on the clear liquid, and freeze-drying to obtain a crude product of pueraria isoflavones, wherein the purity of the pueraria isoflavones is not less than 11percent, and the extraction ratio of isoflavone is not less than 92 percent. The method has advantages of short extracting time, little solvent consumption, and low extracting cost.

Description

technical field [0001] The invention relates to a method for efficiently extracting kudzu root isoflavones from kudzu root waste materials, which is a method of using liquid CO 2 A new method of obtaining Pueraria isoflavones from puffed Pueraria radicis waste material by ultrasonic extraction. Background technique [0002] Pueraria isoflavones (mainly puerarin) are the main active ingredients of Pueraria root; they have various pharmacological effects such as antiarrhythmia, lowering blood fat, dilating cerebral blood vessels, increasing cerebral blood flow, improving microcirculation, etc. Its curative effect is good and widely used in clinical practice. It is used in the treatment of cardiovascular and cerebrovascular diseases, hyperlipidemia and diabetes. In the production process of kudzu root powder in most areas of my country, the slag after washing pueraria powder is discarded and considered to be of no use value. But it is precisely these waste residues (fibrous s...

Claims

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Application Information

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IPC IPC(8): A61K36/488A61P9/06A61P3/06A61P3/10A61P9/10
Inventor 余顺火吕顺马道荣许跃飞
Owner HEFEI UNIV OF TECH
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