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Application of Piper longum in the preparation of drugs for inhibiting neuroinflammation

The invention relates to a technology of longi and medicine, which is applied to the application field of longi in the preparation of medicines for inhibiting neuroinflammation.

Active Publication Date: 2016-04-13
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report in the literature that Piper longum extract and piperine can inhibit neuroinflammation, and based on this, there are related studies on the treatment of central nervous system diseases

Method used

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  • Application of Piper longum in the preparation of drugs for inhibiting neuroinflammation
  • Application of Piper longum in the preparation of drugs for inhibiting neuroinflammation
  • Application of Piper longum in the preparation of drugs for inhibiting neuroinflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0119] Embodiment 1, the acquisition of Piper longum extract

[0120] The dried fruit of Piper longum in this example is a crude drug, which can be purchased from pharmacies.

[0121] Take the dried fruit of Piper longum, crush it into a coarse powder, extract three times with 85% (volume percentage) ethanol solution 8 to 10 times the weight of the medicinal material, for 1 hour each time, filter, combine the filtrate, and reduce pressure at 60°C (vacuum degree 0.01 Pa) Recover ethanol to a concentrated solution with a relative density of 1.08, dilute the concentrated solution with water, and the ratio of the diluted mass to the dried fruit of Piper longum is 1:1, and then centrifuge at 1500g for 10 minutes. The supernatant after centrifugation was adsorbed by a macroporous adsorption resin column (D101 type), first eluted with 20% (volume percentage) ethanol of 10 times the column volume; then eluted with 70% ethanol of 20 times the column volume, and collected The eluate fr...

Embodiment 2

[0123] Embodiment 2, the acquisition of Piper longum extract

[0124] The dried fruit of Piper longum in this example is a crude drug, which can be purchased from pharmacies.

[0125] Take the dried fruit of Piper longum, crush it into a coarse powder, extract three times with 70% (volume percentage) ethanol solution 8 to 10 times the weight of the medicinal material, each time for 1 hour, filter, combine the filtrate, and reduce pressure at 50°C (vacuum degree 0.01 Pa) Recover ethanol to a concentrated solution with a relative density of 1.0, dilute the concentrated solution with water, and the ratio of the diluted mass to the dried fruit of Piper longum is 1:1, and then centrifuge at 1500g for 10 minutes. The supernatant after centrifugation was adsorbed by a macroporous adsorption resin column (D101 type), first eluted with 20% (volume percentage) ethanol of 10 times the column volume; then eluted with 70% ethanol of 20 times the column volume, and collected The eluate fro...

Embodiment 3

[0126] Embodiment 3, the acquisition of Piper longum extract

[0127] The dried fruit of Piper longum in this example is a crude drug, which can be purchased from pharmacies.

[0128] Take the dried fruit of Piper longum, crush it into a coarse powder, extract three times with 95% (volume percentage) ethanol solution 8 to 10 times the weight of the medicinal material, for 1 hour each time, filter, combine the filtrate, and reduce pressure at 70°C (vacuum degree 0.01 Pa) Recover ethanol to a concentrated solution with a relative density of 1.1, dilute the concentrated solution with water, and the ratio of the diluted mass to the dried fruit of Piper longum is 1:1, and then centrifuge at 1500g for 10 minutes. The supernatant after centrifugation was adsorbed by a macroporous adsorption resin column (D101 type), first eluted with 20% (volume percentage) ethanol of 10 times the column volume; then eluted with 70% ethanol of 20 times the column volume, and collected The eluate fro...

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Abstract

The invention discloses an application of fructus piperis longi or an extract of the fructus piperis longi on preparation of medicine for inhibiting neuroinflammation. The fructus piperis longi extract is obtained by alcohol as an extracting solution. The experiments prove that the fructus piperis longi or the extract of the fructus piperis longi is capable of inhibiting the activation of the microglial cells and alleviating the generation of the neuroinflammation, so that an effect on treating the central nervous system diseases is reached.

Description

technical field [0001] The present invention relates to the application of Piper longum or its extract in the preparation of medicines for inhibiting neuroinflammation, in particular to the application of Piper longum or its extracts in the preparation of medicines for treating central nervous system diseases by inhibiting neuroinflammation. Background technique [0002] The immune system plays an important role in maintaining tissue homeostasis and in responding to infection and injury. Microglia is a resident immune cell in the central nervous system, a member of the mononuclear phagocyte family, and participates in the innate immune response in the brain. Under normal circumstances, microglia play the role of immune surveillance, clearing metabolites through simple swallowing and drinking, and maintaining the purification of tissue stability. Under normal physiological conditions, the brain is considered immune privileged. Indeed, antigen presentation is actively suppre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/67A61P25/28A61P29/00A61K131/00
Inventor 杨慧吴霞曲鹏程段春礼鲁铃铃张建亮
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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