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Quality detection method of blood pressure-lowering and lipid-lowering drugs

A technology of blood lipid-lowering drugs and detection methods, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., and can solve problems such as difficulty in effectively controlling the quality of finished products, inability to ensure product efficacy, and lack of standardized indicators for product quality.

Active Publication Date: 2014-07-09
广西万寿堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

State Drug Administration Standard (Trial) WS-5809(B-0809)-2002 only has TLC identification of camellia and white peony medicinal materials, and does not involve content control methods. It is difficult to effectively control the quality of finished products in production. Different There are no standardized indicators to measure the quality of batch products, and it is impossible to ensure the efficacy of the products, which has a huge impact on clinical treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 cassia mountain green tea

[0026] 1600 grams of mountain green tea, 1600 grams of Panax notoginseng leaves, 1600 grams of cassia seeds, 1600 grams of white peony root, 160 grams of tangerine peel, crush the mountain green tea into coarse powder, add water and decoct the other four flavors for three times; add water 10 times the weight for the first time, decoct For 1 hour, add 8 times the weight of water for the second time, decoct for 1 hour, add 8 times the weight of water for the third time, and decoct for 1 hour; combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.25 (60°C) , add mountain green tea coarse powder, mix well, make granules, dry, make 1000 bags, and get final product.

[0027] Properties: This product is brown granular tea in bag; slightly fragrant, slightly bitter and slightly sweet.

Embodiment 2

[0028] Embodiment 2 Application of the present invention to detect the quality of Cassia Mountain green tea

[0029] Do as follows:

[0030] TLC identification of Panax notoginseng

[0031] Take 4.5g of Cassia mountain green tea, grind it finely, put it in a mortar, grind and extract it with 7% (g / ml) sulfuric acid solution for 3 times, 25ml each time, filter, combine the sulfuric acid extract, put it in a boiling water bath, heat and reflux for 1 hour, Let it cool, extract 3 times with petroleum ether (30-60℃), 30ml each time, combine the petroleum ether extract, evaporate to dryness in a water bath, dissolve the residue in 0.5ml of chloroform, and use it as the test solution; take another 2.4 g, make the reference drug solution in the same way; then take the ginsengdiol reference substance, add absolute ethanol to make a solution containing 0.5mg per 1ml, and use it as the reference substance solution; ) test, draw 10 μl of each of the above three solutions, spot them on ...

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Abstract

The invention discloses a detection method of blood pressure-lowering and lipid-lowering drugs. The quality detection method improves quality detection of the conventional related traditional Chinese materia medica preparation of Jueming mountain Green Tea, and mainly increases thin-layer chromatography identification of sanchi leaf, semen cassia medicinal material and chrysophanol in the semen cassia, and a content determination process of chrysophanol in the semen cassia. The detection method provided by the invention is good in stability and reproducibility, strong in specificity and simple to operate, so that a new quality control specification of the Jueming mountain Green Tea is built. The new quality control specification is capable of helping effectively controlling quality of a finished product in production of Jueming mountain Green Tea and improving a quality level of the Jueming mountain Green Tea, guaranteeing a production technology to be controllable, ensuring a clinical effect, and providing reliable guarantee for stable and definite efficacy of the product.

Description

technical field [0001] The invention belongs to the field of drug quality detection, in particular to a method for detecting blood pressure-lowering and blood-fat-lowering drugs. Background technique [0002] Cassia mountain green tea is a drug for lowering blood pressure and blood fat. It is a tea bag made from mountain green tea, Panax notoginseng leaves, cassia seeds, white peony root, and tangerine peel. Adjuvant treatment of hypertension, hyperlipidemia and dizziness caused by hyperactivity of liver yang. State Drug Administration Standard (Trial) WS-5809(B-0809)-2002 only has TLC identification of camellia and white peony medicinal materials, and does not involve content control methods. It is difficult to effectively control the quality of finished products in production. Different There are no standardized indicators to measure the quality of batch products, and the efficacy of the products cannot be guaranteed, which has a huge impact on clinical treatment. Conte...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/90G01N30/88
Inventor 李修善蒋冰清农常东凌中华
Owner 广西万寿堂药业有限公司
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