Mass control method for medicinal composition for treating hepatitis

Abstract

The invention relates to a mass control method for a medicinal composition for treating hepatitis, in particular to a mass control method for a Jiuwei glucurolactone traditional Chinese medicine. The method comprises the following steps of: authenticating thin-layer chromatography of pseudo-ginseng, rheum officinale and scutellaria baicalensis, namely measuring total content of rheum emodin (C15H10O5) and chrysophanic acid (C15H10O4) by high performance liquid chromatography; and authenticating schisandra chinensis, namely checking rhaponticin and measuring the schizandrin content. By the method, a schisandra chinensis thin-layer authentication control method and a schizandrin content extreme control method are added; and a rhaponticin checking step is added, so that false rheum officinale can be prevented from being mixed into the medicine.

Description

technical field [0001] The invention relates to a quality control method of a medicinal composition for hepatitis, in particular to a quality control method of Jiuwei Gantai traditional Chinese medicine. Background technique [0002] Jiuwei Gantai is a medicine made of Jiuwei pure natural Chinese medicine for the treatment of hepatitis B. Its main functions are to remove stasis and dredge collaterals, soothe the liver and strengthen the spleen. It is used for symptoms of hepatitis B such as hypochondriac pain or tingling pain caused by qi stagnation and blood stasis combined with liver depression and spleen deficiency, depression, loss of appetite, abdominal distension after eating, irregular stool, or mass under the hypochondriac. This product is a pure natural Chinese patent medicine preparation for treating hepatitis B. It is unique among many prescriptions for treating hepatitis B and has a broad market prospect. [0003] However, the current quality standard used for t...

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Problems solved by technology

[0003] However, the current quality standard used for this product cannot effectively control the product quality. Only three of the nine medicinal materials were identified (Notoginseng, rhubarb, and scutellaria baicalensis), and only one of the medicinal materials was determined (emodin in rhubarb). , there is no identification or content limit for other six-flavor medicinal materials. For example, whether the effective content of schisandrin A can be detected in the finished product is unknown, and whether pseudo-rhubarb is used for feeding is unknown.

For example, through the random inspection of Jiuwei Gantai sold in the market, the TLC identification research of Schisandra chinensis and the determination of the content of schisandrin A were carried out. The content result was almost 0, and the TLC identification was not detected. It contains rhubarb, indicating that it is caused by the use of pseudo-rhubarb as ingredients, but these indicators are not included in the current quality control methods, which is seriously detrimental to product quality and curative effect, and is seriously detrimental to the health of ordinary people.

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