Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compound for detecting hexanal exhaled by lung cancer patient

A compound and hexanal technology, which are applied in the field of new compounds for detecting hexanal and their preparation, can solve the problems of complex, time-consuming and expensive lung cancer diagnosis methods, and are suitable for large-scale census, low in price, and fast in detection. Effect

Inactive Publication Date: 2014-05-07
CHONGQING UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide a novel compound for detecting hexanal gas, which is used for the detection of lung cancer by respiratory diagnosis, and solves the problems of complex, time-consuming and expensive conventional diagnostic methods for lung cancer

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound for detecting hexanal exhaled by lung cancer patient
  • Compound for detecting hexanal exhaled by lung cancer patient
  • Compound for detecting hexanal exhaled by lung cancer patient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] The novel compounds of the present invention will be further described in detail below in conjunction with specific examples.

[0023] One, a kind of novel compound for detecting hexanal, its structural formula is:

[0024] ;

[0025] The compound is named: bis-[5-(4-carbonylphenyl)-10,15,20-triphenylporphyrin]-1,2-phthalimide.

[0026] Further, the preparation method of the novel compound for detecting hexanal comprises the following steps:

[0027] The first step, synthesis of monocarboxyporphyrin:

[0028] 1) Add 200mL propionic acid into a 250mL three-necked flask and heat to boiling;

[0029] 2) Add 2.7g of p-carboxybenzaldehyde and 5.5mL of benzaldehyde to the propionic acid treated in step 1), and stir to fully dissolve p-carboxybenzaldehyde;

[0030] 3) Add 5 mL of freshly distilled pyrrole propionic acid solution dropwise to the mixed solution treated in step 2), and stir and reflux for 1 hour;

[0031] 4) Distill out 150mL of propionic acid from the mix...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a novel compound for detecting hexanal exhaled by a lung cancer patient and a preparation method thereof. The structural formula is represented as follows. The compound is called as bis-[5-(4-carbonyl phenyl)-10, 15, 20-triphenyl porphyrin]-1, 2-phthalimide. The compound is obtained by removing two molecules of water from 5-p-carboxyphenyl-10, 15, 20-triphenyl porphyrin and o-phenylenediamine; carboxyl porphyrin with excellent photoelectric properties and the o-phenylenediamine are subjected to condensation reaction to form a molecular tweezer compound with specific cavity sizes; and the compound can be further developed into a sensitive material for visual breath detection of the lung cancer patient. By means of the novel compound, breathing diagnosis of diseases can be performed, and problems that convention diagnosis methods of lung cancers are complicated, time-consuming and expensive and can cause damages to the patient are solved.

Description

technical field [0001] The invention relates to a novel compound for detecting hexanal and a preparation method thereof. Background technique [0002] Lung cancer refers to malignant epithelial tumors of the lung. It originates from the bronchial epithelium, bronchial mucus glands, bronchiole epithelium, and alveolar epithelium. It is called bronchial lung cancer, or lung cancer for short. At present, the morbidity and mortality of lung cancer have been ranked first in various malignant tumors. The incidence and mortality of lung cancer in my country have been on the rise, and about 600,000 people die of lung cancer every year. Clinically, the common diagnostic methods for lung cancer include the following: X-ray examination, computerized tomography, magnetic resonance tomography, sputum exfoliated cell examination, fiberoptic bronchoscopy, and percutaneous lung biopsy. The conventional diagnostic methods for lung cancer mentioned above are complicated, time-consuming and ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D487/22G01N21/25
Inventor 侯长军吴宇法焕宝霍丹群杨眉钟先华
Owner CHONGQING UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com