Leukocyte filter with soft shell and manufacturing method of leukocyte filter

Abstract

The invention discloses a leukocyte filter with a soft shell and a manufacturing method of the leukocyte filter. The leukocyte filter with the soft shell comprises two PVC (Polyvinyl Chloride) external membranes and a filter membrane assembly; the filter membrane assembly is arranged between the two PVC external membranes to form an unfiltered liquid cavity and a filtered liquid cavity; the filter membrane assembly comprises a combined filter membrane as well as two PVC internal membrane rings which are respectively arranged at two sides of the combined filter membranes; the internal edges of the PVC internal membrane rings are in sealed connection with the external edge of the combined filter membrane, and meanwhile, the internal membrane rings are in sealed connection with the edges of the PVC external membranes; the unfiltered liquid cavity is provided with an inlet catheter; and the filtered liquid cavity is provided with an outlet catheter and a support tube. According to the leukocyte filter with the soft shell and the manufacturing method of the leukocyte filter, the soft shell material and the filter membrane are adopted, and the binding site has the characteristics of high fusion strength, good flexibility and strong elasticity; the soft shell material and the filter membrane are capable of resisting high temperature and high pressure without breakage during the steam sterilization, and are not broken during the high-speed centrifugal separation of blood, resulting in leakage; and meanwhile, the leukocyte filter with the soft shell has the advantages of simple and attractive appearance and high utilization rate of materials and is easy to realize mass production.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to a leukocyte filter for safe blood transfusion. Background technique [0002] Modern blood transfusion studies have shown that non-therapeutic leukocytes in blood are a kind of "polluting substance". After allogeneic blood transfusion, leukocyte antibodies will be produced, causing a series of adverse reactions and side effects. Clinical data show that a certain proportion of blood transfusion recipients have different degrees of transfusion reactions, such as: non-hemolytic fever reaction, ineffective platelet transfusion, transfusion-related graft-versus-host disease (GVHD), cytomegalovirus (CMV) infection, etc. Therefore, the removal of leukocytes from blood and its components is of great significance to the safety of blood transfusion and clinical treatment. [0003] In order to improve the safety of blood transfusion, some countries have invented and manufactured various f...

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Problems solved by technology

[0005] The soft shell filters involved in CN200820153904.8 and CN200820021399.1 all have the function of anti-centrifugation, but there is no mention of the filter conditions, and the filter conditions have a great impact on the filter performance. According to the collected market information, domestic filters meet the requirements of Blood filtration refrigerated at 4°C for 6-48 hours, the filtration performance is ideal, but the filtration performance cannot meet the standard requirements when the blood temperature is high

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