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Application of class of indole alkaloids to preparation of marine biofouling prevention coating material

A marine biofouling and indole alkaloid technology, which is applied in the application field of indole alkaloids in the preparation of anti-marine biofouling coatings, can solve the problems of low release rate, destroy blood cells, destroy ecological balance and the like, and achieve good lipophilic effect

Active Publication Date: 2012-10-31
SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Subsequent antifouling coatings that dominate the market are copper-containing antifouling coatings with low release rates. However, heavy metal elements will accumulate in the ocean, especially in harbors, resulting in a large number of algae deaths, affecting carp, shrimp, crabs, etc. And the embryonic growth of various molluscs and backpack animals, destroying their blood cells, thereby destroying their ecological balance, so it will eventually be banned

Method used

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  • Application of class of indole alkaloids to preparation of marine biofouling prevention coating material
  • Application of class of indole alkaloids to preparation of marine biofouling prevention coating material

Examples

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Embodiment 1

[0015] Example 1: Anti-adhesion activity test of marine macrofouling organism barnacle larvae of indole alkaloid compounds represented by formula (1)-formula (4)

[0016] The activity test model is the attachment inhibition test of Barnacles larvae, one of the most commonly used marine fouling biological models in laboratories. Adult barnacles feed on Chaetoceros gracilis Schutt, and culture barnacle nauplii to Venus larva stage in 0.22 μm filtered seawater with 2 larvae per milliliter at 28°C. Activity tests were carried out with the resulting Venus stage larvae. Anti-larval settling activity of compounds was determined using 24-well polystyrene plates. Dissolve the pure product of compound (E)-3-(1H-imidazole-4-yimethylene)-6-(1H-indl-3-ylmethyl)-2,5-piperazinediol (Formula 1) in DMSO and filter with sterile Seawater was diluted into solutions of different concentrations (60–140 μg / mL) as test solutions. Add 1mL test solution and 20±2 mature barnacle larvae to each well, ...

Embodiment 2

[0019] Example 2: Anti-adhesion activity test of indole alkaloid compounds represented by formula (5) to formula (7) against the attachment of larvae of marine macrofouling organisms

[0020] The activity test model adopts the attachment inhibition test of Bugula neritina, one of the most commonly used marine fouling biological models in the laboratory. The collected mature B. multiloculum was placed in seawater filtered with a 0.22 μm filter membrane, stimulated with light, and the larvae produced by the mature B. multiloculum stimulated by light were collected. Larvae were placed in a watch glass containing seawater filtered through a 0.22 μm filter membrane. The activity test was done with the larvae produced by Bryosa larvae by light. Anti-larval settling activity of compounds was determined using 24-well polystyrene plates. The compound fumiquinazoline D (formula 5) was dissolved in DMSO, and diluted with sterile filtered seawater to obtain different concentration solut...

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Abstract

The invention discloses application of a class of indole alkaloids to preparation of a marine biofouling prevention coating material. The (E)-3-(1H-imidazole-4-yimethylene)-6-(1H-indl-3-ylmethyl)-2,5-piperazinediol (figured in formula 1), the meleagrin (figured in formula 2), the glandicoline B (figured in formula 3), the 11alpha-methoxyroquefortine C (figured in formula 4), the fumiquinazoline D (figured in formula 5), the cyclotryprostatins B (figured in formula 6) and the fumiquinozaline G (figured in formula 7), which are provided by the invention, have marine biofouling prevention activity and can be used for preparing the marine biofouling prevention coating material; if the compounds permeate or diffuse into film forming natural resin, polyethylene ethyl acetate copolymer and other polymers such as hydrolyzable, soluble or insoluble resin in an independent or combined way to prepare the marine biofouling prevention coating material, the marine biofouling prevention coating material can release sufficient effective components to a surface to achieve an antifouling function; and as the compounds are natural active ingredients, are hard to dissolve in water but easy to dissolve low-polarity organic solvents such as chloroform and ethyl acetate, and have favorable oleophilic properties, the components can be applied to preparing the marine antifouling agents in an independent or combined way and have a favorable application prospect.

Description

Technical field: [0001] The invention belongs to the field of biology, and in particular relates to the application of a class of indole alkaloids in the preparation of anti-marine biofouling coatings. Background technique: [0002] In the historical process of developing and utilizing the ocean, human beings have always been faced with the problem of preventing and eradicating marine organisms. Marine fouling organisms are a general term for various animals, plants and microorganisms that inhabit or attach to ships and various underwater artificial facilities and adversely affect human economic activities. There are more than 4,000 species of marine fouling organisms in the world, and 614 species have been recorded in my country's coastal areas, among which the most important groups are algae, hydra, eucalyptus, bivalves, barnacles and sea squirts. Marine fouling organisms attach, grow and even form communities on the surface of various objects such as hulls, water pipes, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09D7/12C09D5/16
Inventor 漆淑华贺飞
Owner SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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