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Application of acteoside in preparing medicine for treating alzheimer disease

A technology for Alzheimer's disease and acteoside, applied in the field of medicine

Inactive Publication Date: 2012-10-31
闫明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no relevant reports on the use of acteosides for multi-target treatment of Alzheimer's disease

Method used

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  • Application of acteoside in preparing medicine for treating alzheimer disease
  • Application of acteoside in preparing medicine for treating alzheimer disease
  • Application of acteoside in preparing medicine for treating alzheimer disease

Examples

Experimental program
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Effect test

Embodiment

[0020] The use of a kind of acteoside of the present invention in the preparation of drugs for preventing and treating Alzheimer's disease, the acteoside acts through multiple channels and multi-targets, and the specific experiments are as follows:

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Abstract

The invention relates to an application of acteoside in preparing a medicine for treating alzheimer disease. The acteoside is used for preventing the alzheimer disease by multi-target-point action. The acteoside is synthesized artificially or is obtained from plants. Verified by in vivo and vitro experiments, the acteoside has the advantages that the central cholinergic nervous system can be improved, the level of glutamic acid can be adjusted, the formation and deposition of beta amyloid protein (Abeta) can be inhibited, the action of neuroprotection is achieved, the hyperphosphorylation of tau protein is inhibited, the antioxidant action is achieved, the cerebral circulation is improved, and cholesterol can be reduced, so that the multi-target-point prevention and treatment of the alzheimer disease is realized.

Description

technical field [0001] The invention relates to the multi-target use of acteoside for preventing and treating Alzheimer's disease, which belongs to the field of medicine. Background technique [0002] Alzheimer's disease is a primary gray matter disease. It is characterized by atrophy of the cerebral cortex, accompanied by neurofibrillary tangles and senile plaques. The course of the disease is progressive and eventually leads to dementia, but the etiology is unclear. Cerebrovascular dementia is related to cerebral hemorrhage, cerebral thrombosis, cerebral arteriosclerosis, etc. At present, although the drugs used clinically can improve some symptoms caused by cerebral hemorrhage or cerebral embolism, they are ineffective in improving memory or mental retardation. According to United Nations estimates, the number of elderly people will reach 590 million in 10 years, increasing to 1.1 billion in 2025. AD is not only the biggest health killer of the elderly, but has also bec...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61P25/28
Inventor 闫明霍仕霞高莉彭晓明黄毅
Owner 闫明
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