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Ethyl acetate extract product of Chinese fevervine herb and root and application thereof

A technology of ethyl acetate extraction and ethyl acetate extraction, which is applied in the field of ethyl acetate extract of Gallus chinensis, can solve the problems such as reports on the application of ethyl acetate extract of Gallicia spp.

Active Publication Date: 2012-10-17
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] There is no report on the ethyl acetate extract of Gallus chinensis and its application in anti-senile dementia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: the petroleum ether extract of Caulis chinensis

[0040] Take the whole plant of Gallus chinensis, crush it, pass it through a No. 2 sieve (particle size is 850 μm), take 500 grams of coarse powder, soak it in petroleum ether for 24 hours, and extract it by percolation until the percolation liquid is light in color (equivalent to 5 times the amount of medicinal materials) , collect the percolate, concentrate the percolate under reduced pressure to a relative density of 1.15-1.20, and spray dry to obtain 8.54 g of petroleum ether extract.

Embodiment 2

[0041] Example 2: The ethanol and ethyl acetate extracts of Gallus chinensis

[0042] Take the whole plant of Gallus chinensis and crush it, the particle size is 500 μm, take 500 grams of coarse powder, soak in petroleum ether for 16 hours, extract by percolation until the percolation liquid becomes lighter in color (equivalent to 5 times the amount of medicinal materials), collect the residue and percolate solution, evaporate the residue to dry petroleum ether, extract twice with 3 times the volume of 80% ethanol for 2 hours each time, combine the two extracts, concentrate under reduced pressure until there is no alcohol smell (relative density is 1.15-1.20), to obtain Ethanol concentrate, extract it with ethyl acetate in the same amount (volume) as the ethanol concentrate, release the lower layer, concentrate to dryness to obtain ethanol extract; pour out the upper layer, concentrate to dryness, and obtain 1.20 g of ethyl acetate extract ( The yield was 0.24%).

Embodiment 3

[0043] Example 3: The ethanol and ethyl acetate extracts of Gallopia chinensis

[0044]Take the whole plant of Gallus chinensis and pulverize it, the particle size is 850 μm, take 500 grams of coarse powder, soak it in petroleum ether for 24 hours, extract by percolation until the percolation liquid becomes lighter in color (equivalent to 5 times the amount of medicinal materials), collect the residue and percolate solution, evaporate the residue to dry petroleum ether, extract twice with 3 times the volume of 80% ethanol for 2 hours each time, combine the two extracts, concentrate under reduced pressure until there is no alcohol smell (relative density is 1.15-1.20), to obtain The ethanol concentrate was extracted with ethyl acetate in an amount (volume) equal to that of the ethanol concentrate, and the lower layer was released and concentrated to dryness to obtain an ethanol extract; the upper layer was poured out and concentrated to dryness to obtain 1.50 g of ethyl acetate ...

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PUM

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Abstract

The invention relates to an ethyl acetate extract product of Chinese fevervine herb and root and an application thereof. The ethyl acetate extract product of Chinese fevervine herb and root can substantially inhibit activity of butyrylcholine esterase in AD model. Therefore, the ethyl acetate extract product of Chinese fevervine herb and root can be used to prepare drugs for preventing and treating senile dementia.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, in particular to an ethyl acetate extract of Caulis chinensis and application thereof. Background technique [0002] Chicken dung vine, alias: turtle dove rice, female green, main dung vine, but festival, Jiezhi vine, stinky vine root, cowhide jelly, chicken arrow vine, stinky vine, hair gourd, sweet vine, spiced vine, stinky dog ​​vine, fragrant vine, Bitch vine, white-haired vine, bullshit vine, breeze vine, stinky dung vine, chicken feet vine, Jieshu vine, Yu Mingsha, chicken vine, and sparrow vine. It is the dry whole herb of Paederia scandens (lour.) merr, a plant of the Rubiaceae family. It has the effects of dispelling wind and dampness, relieving pain and detoxification, eliminating food accumulation, promoting blood circulation and reducing swelling. The chemical constituents of Gallus chinensis mainly include volatile oil, iridoid glycosides, flavonoids and other constituents. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P25/28
Inventor 黄林芳
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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