A kind of external pharmaceutical composition for treating skin fungus infection

A technology of topical medicine and skin fungus, which is applied in the field of medicine, can solve problems affecting the quality of life of patients, and achieve the effects of relieving skin burning sensation, shortening the anti-itching time, and enhancing antifungal activity

Active Publication Date: 2016-08-17
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, since terbinafine hydrochloride and butenafine hydrochloride fundamentally treat local skin fungal infections by killing or inhibiting fungi, this will inevitably relieve symptoms such as local skin itching, skin flushing or redness, especially pruritus symptoms take a long time
Therefore, when the patient's itching is unbearable, the itching cannot be relieved quickly, which affects the quality of life of the patient to a certain extent.

Method used

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  • A kind of external pharmaceutical composition for treating skin fungus infection
  • A kind of external pharmaceutical composition for treating skin fungus infection
  • A kind of external pharmaceutical composition for treating skin fungus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1 gel

[0057]

[0058] Preparation process: Dissolve butenafine hydrochloride, miconazole nitrate and loratadine in 1,2-propanediol, then add appropriate amount of distilled water and glycerin, then mix carbopol 940 with polysorbate-80 and 300ml of distilled water, mix well, dissolve sodium hydroxide in 100ml of distilled water, add supernatant and mix well, then dissolve ethylparaben in ethanol, add gradually and stir well, to obtain transparent gel.

Embodiment 2

[0059] Embodiment 2 gel

[0060]

[0061] Triethanolamine to adjust pH to 6.0

[0062] Preparation process: Dissolve butenafine hydrochloride and cetirizine hydrochloride in 1,2-propanediol, then add appropriate amount of distilled water and glycerol, then mix carbopol 940 with polysorbate-80 and 300ml distilled water Mix evenly, adjust the pH value to 6.0 with triethanolamine, then dissolve ethylparaben in ethanol, add gradually and stir evenly, add distilled water to 1000g, and obtain a transparent gel.

Embodiment 3

[0063] Embodiment 3 gel

[0064]

[0065] Adjust pH to 7.0 with triethanolamine

[0066] The preparation process is the same as in Example 2.

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Abstract

In the prior art, squalene cyclooxygenase inhibitors provide unobvious itching relieving effects for treatment of fungus infection. In order to over the disadvantage of the squalene cyclooxygenase inhibitors, the present invention provides an external application drug composition containing a squalene cyclooxygenase inhibitor and an H1 receptor blocker, wherein the drug composition has characteristics of fungus killing, synergistic anti-inflammatory and synergistic itching relieving, and symptoms of fungus infection of superficial skin can be significantly improved with the drug composition.

Description

[0001] This application is a divisional application of the patent application with the application number 200910211355.4 and the invention name "an external pharmaceutical composition for treating skin fungal infection" submitted on October 31, 2009. technical field [0002] The invention belongs to the field of medicine, in particular to an external pharmaceutical composition for treating skin fungus infection. Background technique [0003] Superficial skin fungal infectious diseases account for a high proportion of skin diseases, are generally easy to relapse, and are difficult to cure, and belong to one of the intractable skin diseases. Clinically common skin fungal infectious diseases include tinea manuum, tinea pedis, jock itch, tinea corporis, tinea capitis, etc. The symptoms are mainly manifested in local skin moist flushing, erosion, maceration and whitish or small blisters, unbearable itching of the skin, erysipelas and lymphangitis often caused by secondary infecti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4545A61K31/137A61K31/495A61K31/445A61K31/496A61K31/4174A61K31/4196A61P31/10A61P17/00A61P17/04A61P29/00
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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