External used medicine composition for treating mycotic infection

A technology for topical medicine and fungal infection, applied in the field of medicine, can solve the problem of slow itching relief, achieve the effects of short antipruritic time, shorten antipruritic time, and improve the cure rate

Active Publication Date: 2011-05-11
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] In order to solve the problem that butenafine hydrochloride combined with urea compound ointment treats fungal infections such as tinea pedis and relieves itching slowly, the present invention provides an external pharmaceutical composition for treating fungal infections, which has the advantages of rapid antipruritic, severe keratosis and itching It has a very good therapeutic effect on patients with unbearable severe tinea pedis and other fungal infections

Method used

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  • External used medicine composition for treating mycotic infection
  • External used medicine composition for treating mycotic infection
  • External used medicine composition for treating mycotic infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1 compound cream

[0056] Preparation process: first heat glycerol monostearate and stearic acid on a water bath to dissolve, then add white petrolatum and heat to 70°C-80°C and keep it to form an oil phase; Butenafine hydrochloride, loratadine Dissolve in 1,2-propanediol and an appropriate amount of water, then add polysorbate-80, benzalkonium bromide, add urea and stir, add water to 1000g, stir well and heat to 70°C-80°C and keep it to form a water phase ; Finally, slowly add the oil phase to the water phase, stir while adding, until it condenses, and check the finished product.

Embodiment 2

[0057] The preparation process of embodiment 2 and embodiment 3 is the same as embodiment 1.

[0058] Embodiments 1-3 are given in the form of tables, see Table 1 for details.

[0059] Table 1 emulsifier is the compound cream of stearic acid, glyceryl monostearate and polysorbate-80

[0060]

[0061]

Embodiment 4

[0062] Embodiment 4 compound cream

[0063] Preparation process: first heat and dissolve sodium lauryl sulfate, sodium stearate, and stearyl alcohol on a water bath, then add liquid paraffin and heat to 80°C to form an oil phase; mix butenafine hydrochloride, loratadine Dissolve in glycerol and an appropriate amount of water, then add urea and methylparaben, add water to 1000g, and heat to 80°C to form a water phase; finally, slowly add the oil phase to the water phase, stirring while adding, until Condensate and inspect the finished product.

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Abstract

The invention provides an external used medicine composition for treating mycotic infection, which aims to solve the problem that when a patient uses butenafine hydrochloride and urea compound ointment together to treat severe keratinization and itching tinea pedis, local symptoms, particularly itching, can not be improved quickly. The medicine composition including active ingredients of butenafine hydrochloride, loratadine and urea has the characteristics of short itching relieving time and fast action; besides, butenafine hydrochloride and loratadine have synergic anti-inflammatory activity.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to an external pharmaceutical composition for treating fungal infection. Background technique [0002] Fungal infectious diseases account for a high proportion of skin diseases, are generally easy to relapse, and are difficult to cure, and belong to one of the intractable skin diseases. Clinically common skin fungal infectious diseases include tinea manuum, tinea pedis, jock itch, tinea corporis and tinea capitis, etc., which can be contagious. Its symptoms are mainly manifested in local skin moist flushing, erosion, impregnated whitish or small blisters, skin itching unbearable, often caused by secondary infection after scratching, erysipelas, lymphangitis, etc., easy to keratosis and desquamation after drying chapped etc. The fungi that cause skin infections mainly include Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton gypsum, Trichophyton violaceum, Pityrophyton furfur, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4545A61K31/137A61K31/17A61P31/10
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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