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Application of deoxyschizandrin in preparation of drug for treating cholestasis liver injury

A technology of schisandrin A and bile acid, applied in the application field of medicine, can solve the problem that there is no particularly effective method for the treatment of such diseases, improve the degree of necrosis of liver cells, reduce the synthesis of bile acid, and have high bioavailability. Effect

Inactive Publication Date: 2012-10-17
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no effective method for the treatment of these diseases

Method used

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  • Application of deoxyschizandrin in preparation of drug for treating cholestasis liver injury
  • Application of deoxyschizandrin in preparation of drug for treating cholestasis liver injury
  • Application of deoxyschizandrin in preparation of drug for treating cholestasis liver injury

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Effect test

experiment example 5

[0016] EXPERIMENTAL EXAMPLE Protective effect of schisandrin A on bile acid stasis liver injury in mice induced by lithocholic acid

[0017] 1. Materials and methods

[0018] (1) Experimental equipment

[0019] 1. PCR instrument: GeneAmp PCR System2400 (PE Applied Biosystem);

[0020] 2. Fluo star microplate well reader: Germany BMG company;

[0021] 3. Electronic precision balance: Germany Sartorius BS110S;

[0022] 4. Refrigerated centrifuge: Heraeus Labofuge400R;

[0023] 5. Rotary water bath constant temperature oscillator: Jiangsu Taicang Experimental Equipment Factory Peiying DSHZ-300A;

[0024] 6. Constant temperature air bath oscillator: Jiangsu Taicang Experimental Equipment Factory THZ-C constant temperature oscillator;

[0025] 7. Vortex oscillator: Zhejiang Lecheng Electric Factory XH-89 type;

[0026] 8. Protein electrophoresis electrotransfer equipment: American Bio-RAD mini protein3;

[0027] 9. UV-visible spectrophotometer: American Beckman DU64...

Embodiment 1

[0071] Taking schisandrin A as a raw material drug, adding conventional excipients, and preparing tablets according to a conventional process, for treating liver injury caused by bile acid stasis. Each tablet contains Schizandrin A 100mg, 2 times a day, 1 tablet each time.

Embodiment 2

[0073] Taking schisandrin A as a raw material drug, adding conventional excipients, and preparing capsules according to a conventional process, for treating liver injury caused by bile acid stasis. Each capsule contains Schizandrin A 100mg, 2 times a day, 1 capsule each time.

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PUM

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Abstract

The invention discloses an application of deoxyschizandrin in preparation of drug for treating cholestasis liver injury. Deoxyschizandrin has molecular formula of C24H32O6 and molecular weight of 416.51, and has the structural formula shown in the description. Mouse liver injury induced by application of excessive lithocholic acid (LCA) is taken as a model. After application of deoxyschizandrin, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in serum are significantly lowered, while necrosis degree of liver cells is significantly improved. The results indicate that deoxyschizandrin has treatment effect for liver injury induced by LCA, and can be used for treating cholestasis liver injury clinically.

Description

technical field [0001] The invention relates to a new application of schisandrin A, an active ingredient of traditional Chinese medicine, in particular to the application of schisandrin A in the preparation of medicines for treating intrahepatic bile acid stasis, and belongs to the field of pharmaceutical industry. Background technique [0002] Intrahepatic cholestasis (intrahepatic cholestasis) refers to the obstruction of bile secretion by liver cells due to various reasons, resulting in intrahepatic cholestasis and increased bile components in the blood without biliary obstruction, which is called intrahepatic cholestasis. Lithocholic acid (LCA) is a secondary bile acid that is converted from cholesterol. The specific transformation process is: cholesterol is first hydroxylated in the smooth surface endoplasmic reticulum of liver cells, and then the side chain is oxidized in the mitochondria to generate free primary bile acids (primary bile acibs), mainly trihydroxycholic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/09A61P1/16A61P3/00
Inventor 高月王宇光刘浩生陆倍倍肖成荣谭洪玲马增春梁乾德汤响林
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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