Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of GGPPS genes in preparation of medicines for treating non-alcoholic fatty liver disease

A non-alcoholic and fatty liver technology, applied in the field of GGPPS gene in the preparation of drugs for the treatment of non-alcoholic fatty liver, to achieve good application prospects and slow down the effect of liver lipid accumulation and sex change

Inactive Publication Date: 2015-03-18
NANJING UNIV
View PDF1 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have reported that using GGPPS as a drug target can improve osteoblast differentiation and bone construction (Weivoda and Hohl 2011), and some studies have also demonstrated that GGPPS can be used as a therapeutic target for lung diseases caused by cigarette smoke (Shen, Gong et al. 2011), but there is no report on the target drug between GGPPS for the treatment of non-alcoholic fatty liver

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of GGPPS genes in preparation of medicines for treating non-alcoholic fatty liver disease
  • Application of GGPPS genes in preparation of medicines for treating non-alcoholic fatty liver disease
  • Application of GGPPS genes in preparation of medicines for treating non-alcoholic fatty liver disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

Embodiment 2

Embodiment 3

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an application of GGPPS serving as a target for treating non-alcoholic fatty liver disease. A GGPPS antagonist disclosed by the invention can reduce genetic expression related to lipid accumulation of the liver. The liver-specific knockout GGPPS disclosed by the invention is capable of retarding the lipid accumulation and degeneration of the liver, reducing the level of aspartate transaminase (AST) and alanine aminotransferase (ALT) and protecting the liver functions.

Description

technical field [0001] The invention relates to the use of GGPPS gene in the preparation of medicine for treating nonalcoholic fatty liver. Liver-specific GGPPS knockout and GGPPS antagonist can reduce liver lipid accumulation and have significant effect on treating nonalcoholic fatty liver. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome characterized by fatty degeneration and lipid accumulation in hepatic cells without a history of excessive alcohol consumption but with pathological changes similar to alcoholic fatty liver disease (AFLD). Its disease spectrum includes four pathological stages from mild to severe: simple fatty liver, steatohepatitis (NASH), fatty liver fibrosis and fatty liver cirrhosis. In recent years, due to changes in lifestyle and dietary structure, NAFLD has attracted more and more attention along with the increase of obesity, type 2 diabetes, dyslipidemia and other metabolic related diseases....

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K48/00A61P1/16
Inventor 李朝军薛斌姜珊石梦月沈宁
Owner NANJING UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com