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Novel applications of cape jasmine extract product in preparation of drugs

A kind of gardenia extract, gardenia technology, applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve the problem of weak effect and the like

Inactive Publication Date: 2012-10-10
BEIJING ZHONGYAN TONGRENTANG CHINESE MEDICINE R & D
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After ligation of the common bile duct in rabbits, the bilirubin in the blood decreased by oral administration of gardenia water extract. effect, but slightly weaker than water extract

Method used

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  • Novel applications of cape jasmine extract product in preparation of drugs
  • Novel applications of cape jasmine extract product in preparation of drugs
  • Novel applications of cape jasmine extract product in preparation of drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0113] Take 100 kg of gardenia, add 1500 kg of water, heat and boil for 1 hour, and extract twice respectively. The two drug solutions obtained were combined and concentrated by thin film evaporation to a density of 1.25 g / ml (measured at 60°C). Continue to evaporate in a water bath until the density is 1.35g / ml (measured at 60°C), place it in a drying oven, and dry it under reduced pressure under vacuum to a constant weight to obtain 29.6 kg of gardenia extract, add conventional excipients, and make capsules according to conventional processes Take 2 capsules per day, each capsule contains 5g of gardenia extract, which is used to treat myocardial ischemia.

Embodiment 2

[0115] Take 100 kg of gardenia, add 1500 kg of water, heat and boil for 1 hour, and extract twice respectively. The two drug solutions obtained were combined and concentrated by thin film evaporation to a density of 1.25 g / ml (measured at 60°C). Continue to evaporate in a water bath to a density of 1.35g / ml (measured at 60°C), place in a drying oven, and dry under reduced pressure in a vacuum to a constant weight to obtain 29.6 kg of gardenia extract, add conventional excipients, and make tablets according to conventional processes Take 2 tablets per day, each tablet contains 5g of gardenia extract, which is used for the treatment of myocardial infarction.

Embodiment 3

[0117] Take 100 kg of gardenia, add 1500 kg of water, heat and boil for 1 hour, and extract twice respectively. The two drug solutions obtained were combined and concentrated by thin film evaporation to a density of 1.25 g / ml (measured at 60°C). Continue to evaporate in a water bath to a density of 1.35g / ml (measured at 60°C), place in a drying oven, and dry under reduced pressure in a vacuum to a constant weight to obtain 29.6 kg of gardenia extract, add conventional excipients, and make tablets according to conventional processes Take 2 tablets per day, each tablet contains 5g of gardenia extract, which is used for the treatment of acute myocardial ischemia caused by coronary heart disease and restenosis after transcutaneous coronary angioplasty (PTCA).

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Abstract

Through experiments, the invention proves applications of a cape jasmine and a cape jasmine extract product in the preparation of drugs for treating myocardial infarction, coronary heart disease, myocardial ischemia and cardiac arrhythmia, especially to an application in treatment of acute myocardial ischemia or myocardial ischemia of coronary heart disease caused by restenosis after percutaneous transluminal coronary angioplasty (PTCA). In addition, it is proved through experiments that the above various kinds of applications are accomplished by protection of cardiac muscle and cardiac muscle cell from damage or resistance against inflammatory lesion and oxidative damage of cardiac muscle cell. And an effective dose of cape jasmine and the cape jasmine extract product in a unit preparation is obtained by detection.

Description

technical field [0001] The present invention relates to a new use of a gardenia extract, in particular to a use of a gardenia extract in preparing medicines for treating myocardial infarction, coronary heart disease, myocardial ischemia and arrhythmia. Background technique [0002] Gardenia, the fruit of Rubiaceae Gardenia iasminoides Ellis, bitter cold in nature, non-toxic. Evergreen shrubs, 0.5-2 meters high, with fine hairs on young branches. It often grows in warm sparse forests in low mountains or on barren slopes, beside ditches and roadsides. The roots, leaves and flowers are all used for medicinal purposes. Go into the heart, liver, lung, stomach warp. Can clear away heat and purify fire and cool blood. It is clinically used for acute jaundice hepatitis, hemostasis, sprains and other diseases. Gardeniae mainly contains flavonoids gardenia, pectin, tannin, crocin, crocetin, D-mannitol, nonacane, and β-sitosterol. In addition, it contains a variety of glycosides ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61P9/06A61P9/10
Inventor 连增林陈霞靳冉张翰涛张加晏迟玉明
Owner BEIJING ZHONGYAN TONGRENTANG CHINESE MEDICINE R & D
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