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Method for extracting baicalin from scutellaria baicalensis

A technology for baicalin and scutellariae, which is applied in the field of extracting baicalin from scutellaria baicalensis, can solve the problems that the content of baicalin cannot meet the requirements of the Pharmacopoeia, the product yield is low, and the energy consumption is large, and achieves stable yield, stable product quality, and high production efficiency. The effect of high safety factor

Active Publication Date: 2012-09-19
SICHUAN JISHENGTANG PHARMLS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN1454899A discloses a process of water extraction and acid precipitation of baicalin. The process needs to keep the precipitate obtained after acid precipitation at 70-80°C for more than 12 hours. This step consumes a lot of energy, and the content of baicalin in the obtained product cannot reach Pharmacopoeia requirements, must be purified again
[0006] US6290995 reported a method of adding activated carbon to purify after acid precipitation 1 time, but we found that the product yield was very low by repeating the experiment

Method used

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  • Method for extracting baicalin from scutellaria baicalensis
  • Method for extracting baicalin from scutellaria baicalensis
  • Method for extracting baicalin from scutellaria baicalensis

Examples

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Effect test

Embodiment 1

[0078] Scutellaria baicalensis medicinal material 1Kg, pulverized, passed through a No. 1 sieve (2000 microns), extracted with 10 times the amount of water at 90°C for 2 hours for the first time, extracted for 2 hours with 10 times the amount of water at 90°C for the second time, and filtered. Heat the extract to 80°C, adjust the pH to 2.0 with concentrated hydrochloric acid while stirring, keep it warm at 80°C for 1 hour, let it stand for 4 hours, pour off the supernatant, leave the remaining precipitate and a small amount of liquid to stand for 18 hours, filter, wash with water, and dry The crude product was obtained, about 142.5g. Add 12 times the amount of water (1.71Kg) to the crude product to suspend, heat to 80°C, adjust the pH to 7.5 with 20% sodium hydroxide under stirring, then adjust the pH to 6.5 with concentrated hydrochloric acid, add 1.6% activated carbon (27.36g), Heating, stirring, boiling for 0.5 hours, and filtering. The filtrate was heated to 80°C, adjuste...

Embodiment 2

[0082] Scutellaria baicalensis medicinal material 1Kg, pulverized, passed through a No. 1 sieve (2000 microns), extracted with 15 times the amount of water at 80°C for 1.5 hours for the first time, extracted with 8 times the amount of water at 80°C for 1.5 hours for the second time, and filtered. Heat the extract to 80°C, adjust the pH to 1.8 with concentrated hydrochloric acid while stirring, keep it warm at 80°C for 1 hour, let it stand for 4 hours, pour off the supernatant, leave the remaining precipitate and a small amount of liquid to stand for 12 hours, filter, wash with water, and dry The crude product was obtained, about 142.5g. Add 15 times the amount of water (2.14Kg) to the crude product to suspend, heat to 80°C, adjust the pH to 7.0 with 20% sodium hydroxide under stirring, then adjust the pH to 6.3 with concentrated hydrochloric acid, add 1.0% activated carbon (21.40g), Heating, stirring, boiling for 0.5 hours, and filtering. The filtrate was heated to 80°C, adju...

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Abstract

The invention provides a method for extracting baicalin from scutellaria baicalensis. According to the method, active carbon purification and acid precipitation purification are combined, and finally the scutellaria baicalensis extract of which the quality meets the pharmacopoeia standard is obtained. The method has the advantages of no organic solvent, low cost, easiness in operation and suitability for industrial large-scale production.

Description

technical field [0001] The invention relates to a method for extracting Chinese medicinal materials, in particular to a method for extracting baicalin from Scutellaria baicalensis. Background technique [0002] Scutellaria baicalensis is the dry root of Scutellaria baicalensis Georgi, a plant in the Labiatae family, which has the effects of clearing away heat and dampness, purging fire and detoxification, stopping bleeding and preventing miscarriage. Baicalin is one of the main active ingredients of Scutellaria baicalensis. It has significant biological activity. It has been proved pharmacologically that it has antibacterial, heat-clearing, blood pressure-lowering, sedative, diuretic, choleretic, anti-inflammatory, anti-allergic, detoxification, anti-cancer, etc. effect. At present, baicalin has been successfully developed into baicalin tablets and baicalin capsules for the treatment of acute and chronic hepatitis; in addition, the combination of baicalin and andrographolid...

Claims

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Application Information

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IPC IPC(8): C07H17/07C07H1/08
Inventor 任治军杨刚郑强
Owner SICHUAN JISHENGTANG PHARMLS
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