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Preparation method of L-homoarginine hydrochloride

A technology of homoarginine hydrochloride and lysine, applied in the field of preparation of L-homoarginine hydrochloride, which can solve the problems of inconvenient large-scale production, long reaction time, complicated post-treatment, etc. , achieve the effect of shortening the reaction time, high reaction yield and reducing production cost

Inactive Publication Date: 2013-11-27
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The disadvantages of using the above method to prepare L-homoarginine hydrochloride are: the reaction time is too long, the aftertreatment is complicated, and the yield is low, which is not convenient for large-scale production

Method used

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  • Preparation method of L-homoarginine hydrochloride

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Comparison scheme
Effect test

Embodiment 1

[0011] The preparation method of the L-homoarginine hydrochloride provided in this embodiment comprises the following steps:

[0012] 1. Weigh 44.6g of L-lysine, add 150mL of water to dissolve, and prepare L-lysine solution, and dissolve 26.3g of CuCl 2 2H 2 O was added to the L-lysine solution, and stirred at 20°C for 1.5 hours to obtain a reaction solution A, which was blue in color;

[0013] 2. Weigh 45.8g of O-methylisourea hemisulfate, dissolve it in 100mL of NaOH solution with a mass percentage concentration of 10%, and then add it to the reaction solution A to obtain the reaction solution B, adjust the reaction solution B with 60mL of ammonia water When the pH value reaches 10.60, the blue color becomes lighter;

[0014] 3. Stir the pH-adjusted reaction solution B at 20°C for 24 hours, and then put it in the fresh-keeping layer of the refrigerator (at a temperature of 3°C) for 12 hours. A blue slurry precipitates out, and then quickly filters it to obtain the The sol...

Embodiment 2

[0018] The preparation method of the L-homoarginine hydrochloride provided in this embodiment comprises the following steps:

[0019] 1. Weigh 300g of L-lysine, add 1L of water to dissolve it, and make L-lysine solution, mix 180g of CuCl 22H 2 O was added to the L-lysine solution, and stirred at 30°C for 2.5 hours to obtain a reaction solution A, which was blue in color;

[0020] 2. Weigh 308g of O-methylisourea hemisulfate, dissolve it in a NaOH solution with a concentration of 10% by mass, then add it to the reaction solution A to obtain the reaction solution B, adjust the pH of the reaction solution B with 320mL of ammonia water When the value reaches 10.60, the blue becomes lighter;

[0021] 3. Stir the pH-adjusted reaction solution B at 30°C for 24 hours, then put it into the fresh-keeping layer of the refrigerator (at a temperature of 3°C) for 12 hours, a blue slurry precipitates out, and then quickly filters it to obtain the The solid was dried in a vacuum oven for 3...

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Abstract

The invention relates to the technical field of chemical raw material production, and particularly discloses a preparation method of L-homoarginine hydrochloride. The preparation method of L-homoarginine hydrochloride provided by the invention comprises the steps of: based on L-lysine as a starting raw material, firstly reacting L-lysine with copper chloride dihydrate to generate di-lysine copper complex to protect alpha-NH2, further carrying out carbamide treatment on omega-NH2 to obtain di-homoarginine copper complex, and then carrying out decopperization, impurity removal and acidification to obtain end product L-homoarginine hydrochloride. The preparation method of L-homoarginine hydrochloride provided by the invention is mild in reaction conditions, simple in operation, low in production cost and high in product purity, and is suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of chemical raw material production, in particular to a preparation method of L-homoarginine hydrochloride. Background technique [0002] L-homoarginine is a non-protein amino acid, it is a homologue with arginine, only one more methylene group than arginine, so it has similar properties to arginine. L-homoarginine is often used as a pharmaceutical intermediate for the synthesis of polypeptides. It is clinically used as an ammonia antidote to treat ammonia metabolism disorders caused by liver diseases. It can also change food absorption, the concentration of essential amino acids in tissues and the activity of arginase. L-homoarginine is a strong basic amino acid, which can easily absorb CO in the air 2 , so it is often made into homoarginine hydrochloride for preservation. The existing method for synthesizing L-homoarginine hydrochloride generally uses copper compounds to protect α-NH 2 , followed by ω-N...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C279/14C07C277/08
Inventor 卢伟伟宋应利李国芝张军赵爽
Owner HENAN UNIV OF SCI & TECH
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