Patch for treating rheumatic arthritis and preparation method thereof

A technology for rheumatoid arthritis and arthritis, applied in the field of pharmaceutical preparations, can solve the problems of no patch and no preparation method, and achieve the effects of simple preparation method, convenient use and low investment

Inactive Publication Date: 2015-04-15
FUJIAN ACAD OF MEDICAL SCI
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many research reports and patents about the patch, but there is no patch specifically for triptolide and lidocaine, so there is no preparation method

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Patch for treating rheumatic arthritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] A patch for treating rheumatoid arthritis is composed of a main drug for treating rheumatoid arthritis, a drug solvent, an adhesive, a matrix and a transdermal absorption enhancer, and the main drug is triptolide and relieves rheumatoid arthritis. Lidocaine hydrochloride is an analgesic for inflammation pain.

[0021] The drug solvent is chloroform.

[0022] Adhesive and patch base is high molecular weight polyisobutylene oppanol B 100 and low molecular weight polyisobutylene Oppanol B 12 .

[0023] The transdermal absorption enhancer is one or two of lauryl alcohol, azone (azone), borneol, camphor, and isopropyl myristate (IPM).

[0024] A kind of optimal weight ratio of each component of patch for the treatment of rheumatoid arthritis is: main ingredient (1): main ingredient (2): transdermal absorption penetration enhancer: adhesive and patch base and solvent= 0.1~1‰: 2‰: 1~10%: 65~95%.

[0025] A formulation for treating rheumatoid arthritis patch is:

[0026] ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
Login to view more

Abstract

The invention discloses a patch for treating rheumatic arthritis and a preparation method thereof. The patch consists of a main medicament for treating rheumatic arthritis, a medicament solvent, a substrate and a penetrating agent, wherein the main medicament consists of triptolide and lidocaine serving as a pain-relieving medicament for relieving rheumatic arthritis pain. The patch is medical controlled-release slow release preparation, has a comprehensive pharmacological action, is used for blocking major development pathologic loops of the rheumatic arthritis disease, and has high specificity and a lasting pharmacological effect; and the preparation method is simple.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations and a preparation method, in particular to a patch for treating rheumatoid arthritis with local analgesia and a preparation method thereof. Background technique [0002] A patch is a sheet-like preparation applied to the human skin, in which the drug is transdermally absorbed into the local target tissue or systemic circulatory system, including patches for local skin delivery and transdermal delivery. The patch belongs to the transdermal delivery system, and it is a drug preparation with better performance, which can keep the blood drug concentration stable within the effective concentration range of the treatment; because it avoids the first-pass effect of the drug orally through the gastrointestinal tract and liver, it is more effective than oral administration. The more stable drug administration directly into the blood stream can improve the predictability of the drug in the body; i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/585A61K31/165A61K9/70A61P19/02A61P19/04A61P29/00
Inventor 林绥阙慧卿彭华毅钱丽萍黄郑隽
Owner FUJIAN ACAD OF MEDICAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap