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HLA-A*0201 restrictive CTL epitope of neuritin protein, and application of HLA-A*0201 restrictive CTL epitope

An HLA-A, restricted technology, applied in the field of biomedicine, to achieve the effect of good development and application prospects

Inactive Publication Date: 2012-09-12
中国人民解放军南京军区福州总医院四七六医院
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Problems solved by technology

And it has been reported in the literature that the injection of 3T3 cells transfected with neuritin into nude mice can lead to the formation of tumors in the corresponding parts

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  • HLA-A*0201 restrictive CTL epitope of neuritin protein, and application of HLA-A*0201 restrictive CTL epitope
  • HLA-A*0201 restrictive CTL epitope of neuritin protein, and application of HLA-A*0201 restrictive CTL epitope
  • HLA-A*0201 restrictive CTL epitope of neuritin protein, and application of HLA-A*0201 restrictive CTL epitope

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Embodiment Construction

[0021] In order to make the purpose, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0022] 1. Prediction of Neuritin HLA-A*0201 restricted CTL epitope

[0023] 1. Prediction of CTL epitopes by supermotif scheme

[0024] A supermotif refers to a peptide motif in which the antigenic peptides accepted by HLA allotype molecules in the same HLA family, or even in different families, have the same and similar anchoring residues. The main anchor residues of the supermotif are the amino acid residues at the 2nd (P2) and 9th (P9) positions of the peptide chain. When the amino acid residues at the P2 and P9 positions are V, L, I, M or T, The peptide has a high affinity with HLA-A*0201; when the amino acid residues at positions P2 and P9 are A, I, L, M, V or T, the peptide has a higher affinity with HLA-A*0201. Using SYFPEITHI online software (http: / / w...

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Abstract

The invention pertains to the field of biomedicine, relates to an antigen cytotoxic T cell (CTL) epitope, and particularly relates to a HLA-A*0201 restrictive CTL epitope of a neuritin protein. The amino acid sequence of the HLA-A*0201 restrictive CTL epitope is showed as SEQ ID No.1, SEQ ID No.2 or SEQ ID No.3. The invention also relates to an application of the CTL epitope in preparation of tumor therapeutic peptide vaccines. The CTL epitope can bind to HLA-A*0201 with a high affinity, such that a stable composite is obtained, peptide specific CTL responses can be induced, the peptide specific CTL is stimulated to secrete a high level of IFN-gamma, and specificity killing effect on tumour cells is produced. The CTL epitope can be used to prepare tumor therapeutic peptide vaccine such as glioma therapeutic peptide vaccine, and has potential and good development and application prospects in the field of tumor specific immune therapy.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to an antigen cytotoxic T cell (CTL) epitope, in particular to an HLA-A*0201-restricted CTL epitope of neuritin protein, and also relates to the application of the CTL epitope. Background technique [0002] Glioma is a common primary intracranial tumor of the central nervous system, with an average rate of 40-50% in domestic statistics. It is now clear that chemotherapy can prolong the survival of some glioma patients, but the effect is still not satisfactory. With the rapid development of molecular bioscience and technology, the molecular level of tumors and the pathogenesis of some molecules involved in invasion, metastasis, growth and proliferation, and angiogenesis have become more and more known. Molecular therapy of tumors has gradually shown an increasingly important position. [0003] Tumor-specific immunotherapy is a rapidly developing tumor treatment method in recent years because...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06A61K39/00A61P35/00
Inventor 袁邦清鲜荣华陈羽健马建芳
Owner 中国人民解放军南京军区福州总医院四七六医院
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