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Synthetic method of 2-thiofuran ethylamine

A technology of thienylethylamine and its synthetic method, applied in the direction of organic chemistry, etc.

Inactive Publication Date: 2012-09-12
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0013] The technical problem to be solved by the present invention is to solve the problem of low yield and too long reaction time in the prior art, and then provide a high yield and short reaction time , environmental friendliness, be suitable for the synthetic method of the 2-thienylethylamine of suitability for industrialized production

Method used

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  • Synthetic method of 2-thiofuran ethylamine
  • Synthetic method of 2-thiofuran ethylamine
  • Synthetic method of 2-thiofuran ethylamine

Examples

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Embodiment 1

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Embodiment 2

[0024] Example 3

Embodiment 3

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Abstract

The invention discloses a synthetic method of 2-thiofuran ethylamine. The method comprises the following steps of: cooling sodium borohydride and tetrahydrofuran, dropwise adding a boron trifluoride diethyl ether solution in a nitrogen atmosphere, and preserving heat for continually reacting; adding a solution consisting of 2-nitroethylene thiofuran and tetrahydrofuran into a reaction solution, reacting, heating, and continually reacting; and adding a hydrazine hydrate and RaneyNi, performing a reflux reaction, cooling, extracting with methylene dichloride, drying and distilling to obtain 2-thiofuran ethylamine. The method has the characteristics of high yield, low production cost, short reaction time, environmental friendliness and the like, and has industrial application prospect.

Description

technical field [0001] The invention relates to a method for synthesizing 2-thiopheneethylamine, in particular to a method for synthesizing 2-thiopheneethylamine through reduction using 2-nitroethylenethiophene as a raw material. Background technique [0002] 2-Thienylethylamine is an important chemical intermediate, which can be used to synthesize a variety of compounds, such as hypolipidemic drugs, platelet coagulation inhibitors, cardiovascular relaxants, 5-lipoxygenase inhibitors, antibiotics, etc. Its structural formula is as follows: [0003] [0004] There are many ways to synthesize 2-thienylethylamine. Journal of Wuhan Institute of Chemical Technology, 2002,24 (3): 14-16 publicly reported by 2-nitroethylenethiophene through sodium borohydride, stannous chloride reduction double bond and nitro to obtain 2-thiophene ethylamine respectively, its reaction The equation is: [0005] [0006] The amount of the reducing agent stannous chloride used in this method i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D333/20
Inventor 苗茂谦邢俊德张照昱贾小棐
Owner TAIYUAN UNIV OF TECH
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