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Application of vitamin D3 in preparing medicine for treating multiple myeloma

A multiple myeloma and vitamin technology, which is applied in the field of drug application for treating malignant tumors, can solve the problem of undisclosed dosage of vitamin D in multiple myeloma, and achieve the effects of significant effect, inhibition of tumor growth and clear mechanism of action.

Inactive Publication Date: 2012-08-29
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Vitamin D not disclosed in the prior art 3 Medical use and specific application dosage for multiple myeloma

Method used

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  • Application of vitamin D3 in preparing medicine for treating multiple myeloma
  • Application of vitamin D3 in preparing medicine for treating multiple myeloma
  • Application of vitamin D3 in preparing medicine for treating multiple myeloma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 Vitamin D 3 Capsules

[0044] get vitamin d 3 Add vegetable oil, after dissolving, prepare according to the preparation method of capsules, that is to say. Each Capsule: Contains 125 IU Vitamin D 3 .

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Abstract

The invention discloses medicine for treating multiple myeloma, and particularly relates to application of vitamin D3 and derivatives thereof in preparing a pharmaceutical composition for treating multiple myeloma. The medicine has the principle of treatment that vitamin D3 is mainly acted on a tumour cell Hedgehog (Hh) signaling pathway, and is used for inhibiting accumulation of Smoothened (Smo) protein in the pathway, so that the aim of inhibiting tumor growth is achieved. Compared with bortezomib, the vitamin D3 almost has no toxicity, and in mouse test, no accidental death caused by drug toxicity occurred. The clinical trials indicate that the medicine has a therapeutical effect on patient with types of multiple myeloma, and particularly has a better therapeutical effect for patients after the transplantation of bone marrow. 30 clinical trial patient treatment indicates that the total effective rate achieves 96.7 percent. In addition, the medicine is combined with the bortezomib, so that a synergistic effect is realized.

Description

technical field [0001] The invention belongs to the application field of medicines for treating malignant tumors, in particular to medicines for treating multiple myeloma. Background technique [0002] Vitamin D 3 , also known as niacinamide, cholecalciferol. usually vitamin D 3 It has the following physiological functions: improve the body's absorption of calcium and phosphorus, and make the levels of plasma calcium and phosphorus reach saturation; promote growth and bone calcification, and promote tooth health; increase phosphorus absorption through the intestinal wall, and increase phosphorus through the renal tubules reabsorption; maintain normal levels of citrate in the blood; prevent loss of amino acids through the kidneys. In the patent literature, Chinese patent CN200910140552 introduces vitamin D 3 Induces apoptosis and cytotoxicity against hyperproliferative keratinocytes, while providing a composition containing vitamin D3. Chinese patent CN200480007470 descr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/593A61K31/69A61K38/05A61P35/00
Inventor 杨烨万礼王旻
Owner CHINA PHARM UNIV
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