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Methods for preventing or treating metabolic syndrome

A technology for metabolic syndrome and fat metabolism, applied in metabolic diseases, drug combinations, pharmaceutical formulations, etc., and can solve the problem of unclear specific causes of metabolic syndrome.

Inactive Publication Date: 2012-08-22
CORNELL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The exact cause of metabolic syndrome is unknown, although some of the effects of the disease (such as obesity) and physical inactivity are often underlying causes

Method used

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  • Methods for preventing or treating metabolic syndrome
  • Methods for preventing or treating metabolic syndrome
  • Methods for preventing or treating metabolic syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0248] Example 1 - Treatment of Metabolic Syndrome in Rats Fed a High Fat Diet

[0249] The effect of aromatic-cationic peptides in treating subjects with metabolic syndrome was studied in the Sprague-Dawley rat model over a four-week period. This example describes the results of such experiments.

[0250] in vivo model. A rat model of metabolic syndrome was established by a 6-week combination of HFD and low-dose STZ (streptozotocin) (40 mg / kg) injections in SD rats. The same batch of rats (NRC) fed normal chow were used as controls.

[0251] research group. Arm A: NRC+PBS, subcutaneously, once daily (s.c.q.d.) (Monday to Friday) * , n=5; Group B: HFD+STZ+PBS, subcutaneous injection, once a day (Monday to Friday), n=8; Group C: SS-31 of HFD+STZ+10mg / kg, subcutaneous injection, every Once a day (Monday to Friday), n=8; Group D: HFD+STZ+10 mg / kg SS-20, subcutaneous injection, once a day (Monday to Friday), n=8. Table 7 shows the treatment regimen.

[0252] Table 7. Trea...

Embodiment 2-S

[0262] Example 2 - Effects of SS-20 and SS-31 on Metabolic Syndrome

[0263] This study was conducted to investigate the effect of SS-31 and SS-20 on a model of metabolic syndrome over a 10-week period. Rats were fed a high fat diet for 6 weeks followed by a single dose of STZ (30 mg / kg). The rats were maintained on HFD until 14 weeks after STZ administration. Control rats (NRC) fed normal mouse chow for 6 weeks were then dosed with STZ-free citrate buffer. After 5 months, use SS-31 (10mg / kg, 3mg / kg, 1mg / kg, subcutaneous injection, once a day), SS-20 (10mg / kg, 3mg / kg, subcutaneous injection, once a day) or Vehicle (saline) treated diabetic rats were treated 5 days a week for 10 weeks. The research groups are as follows:

[0264] Group A: HFD / STZ+10mg / kg of SS-31, subcutaneous injection, once a day (Monday to Friday), n=12;

[0265] Group B: HFD / STZ+3 mg / kg of SS-31, subcutaneous injection, once a day (Monday to Friday), n=12; Group C: HFD / STZ+1 mg / kg of SS-31, subcutane...

Embodiment 3

[0271] Example 3 - Effect of SS-20 and SS-31 on diet-induced obesity

[0272] To analyze the pharmacological effects of SS-31 and SS-20 on diet-induced obesity (DIO) in C57BL / 6 mice, test subjects were fed with normal chow or a high-fat diet with the components shown in Table 9.

[0273] Table 9. Food Components

[0274]

[0275] After several days of acclimatization, animals were weighed and randomly assigned to the following treatment groups.

[0276] Table 10. Treatment Groups

[0277] Group

[0278] Animals in groups B through I were switched to the HFD starting from the first day of treatment. During the entire treatment period, perform the following behaviors on specific days.

[0279] Table 11. Treatment options

[0280]

[0281] * On day 23, four animals were sacrificed in all groups. All remaining animals were sacrificed on the last day of the in vivo study (Day 109).

[0282] Dose Preparation & Administration. Treatments were performed once...

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Abstract

The invention provides methods of preventing or treating metabolic syndrome in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application No. 61 / 233275, filed August 12, 2009, which is incorporated herein by reference in its entirety. technical field [0003] The present invention generally relates to methods for preventing or treating metabolic syndrome. In particular, the present invention relates to the administration of an effective amount of an aromatic-cationic peptide to prevent or treat metabolic syndrome or a related disorder in a mammalian subject. Background technique [0004] The following descriptions are provided for the reader's convenience. None of the information presented or references cited is admitted to be prior art to the present invention [0005] Metabolic syndrome is a collection of health disorders or health risks that increase the chance of developing heart disease, stroke, and diabetes. The condition is also known by other names, including Syndrome X and...

Claims

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Application Information

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IPC IPC(8): A61K38/04A61K38/07
CPCA61K38/06A61K38/07A61P3/00A61P3/04A61P3/06A61P3/08A61P3/10A61P5/50A61P7/02A61P9/12A61P13/02
Inventor 黑兹尔·H·司徒
Owner CORNELL UNIVERSITY
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