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Method for separating and purifying monomer compounds from Rhizoma Polygoni Cuspidati

A technology for separation and purification of compounds, applied in the direction of separation/purification of quinones, preparation of organic compounds, chemical instruments and methods, etc., which can solve the problems of serious environmental hazards, complex solvent systems, and high production costs, and achieve short process cycles and high content The effect of high, purity and efficiency improvement

Inactive Publication Date: 2012-08-08
LIAOCHENG UNIV
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The above method is mainly for the separation of a single component, or for the extraction of a mixture, and the resulting product has a low purity, or requires the use of a halogenated hydrocarbon as a solvent, which is seriously harmful to the environment, or the solvent system is relatively complicated and the production scale is small , higher production cost

Method used

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  • Method for separating and purifying monomer compounds from Rhizoma Polygoni Cuspidati
  • Method for separating and purifying monomer compounds from Rhizoma Polygoni Cuspidati
  • Method for separating and purifying monomer compounds from Rhizoma Polygoni Cuspidati

Examples

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Embodiment

[0023] Example: After crushing the medicinal material of Polygonum cuspidatum, put it into a countercurrent percolation system with 3 columns in series percolation columns, use 85% ethanol as the percolation solvent, the medium temperature is 55°C, and the percolation liquid flow rate is 4 times the volume of a single column per hour. The percolation liquid is recovered to be alcohol-free, and then spray-dried to obtain the coarse powder of the knotweed medicinal material extract.

[0024] The coarse powder of Polygonum cuspidatum extract was dissolved in 65% methanol, and subjected to Superose 12 chromatography, and methanol-water was used as the eluent for elution. 254 nm detection, collecting target component fractions, and concentrating the obtained fractions under reduced pressure to obtain the monomer compound to be separated.

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Abstract

The invention relates to a method for separating and purifying polydatin, resveratrol, emodin-8-O-beta-D-glucoside and emodin from Rhizoma Polygoni Cuspidati. The method which treats Rhizoma Polygoni Cuspidati as a raw material comprises the following steps: 1, preparation of Rhizoma Polygoni Cuspidati extracts: taking a well crushed Rhizoma Polygoni Cuspidati medicinal material, percolate-extracting it with ethanol or methanol, recovering the resulting percolate until no alcohol is contained, and spray-drying to obtain crude extract powder; and 2, column chromatography purification: carrying out chromatographic separating purifying by utilizing Superose 12 as a separation medium and methanol-water or ethanol-water as an eluent to obtain high purity monomer compounds of polydatin, resveratrol, emodin-8-O-beta-D-glucoside and emodin. Above processes are green and have no severe harm to the environment.

Description

technical field [0001] The invention belongs to the field of chemical industry, and in particular relates to a method for separating and purifying resveratrol glycoside, emodin-8-O-β-D-glucoside, resveratrol and emodin from traditional Chinese medicine Polygonum cuspidatum. Background technique [0002] Polygonum cuspidatum is the dried root and stem of Polygonum cuspidatum Sieb. et Zucc., a perennial herb of the genus Polygonum, and the leaves are also used as medicine. Polygonum cuspidatum is bitter and cold in nature and taste, and returns to the liver, lung, and gallbladder meridians. The main effects are expelling wind and dampness, eliminating phlegm and relieving cough, clearing heat and detoxification, promoting blood circulation and removing blood stasis. Traditional Chinese medicine is used to treat damp-heat jaundice, lung-heat cough, sore carbuncle, arthralgia, amenorrhea, water and fire burns, traumatic injuries, etc. The main active ingredients in Polygonum c...

Claims

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Application Information

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IPC IPC(8): C07H15/203C07H1/08C07C39/21C07C37/82C07H15/244C07C50/34C07C46/10
Inventor 柳仁民董雯文孙爱玲
Owner LIAOCHENG UNIV
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