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Application of Chinese medicinal composition to preparation of medicament for treating and improving lung PM2.5 deposition

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve the problems of prevention, prevention and improvement that have not yet appeared, and achieve the effects of preventing and improving lung function decline, improving lung function decline, preventing and improving arterial qi and blood

Active Publication Date: 2013-11-20
广州白云山潘高寿药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no medicine to prevent and prevent and improve lung diseases caused by PM2.5 deposition in the lungs

Method used

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  • Application of Chinese medicinal composition to preparation of medicament for treating and improving lung PM2.5 deposition
  • Application of Chinese medicinal composition to preparation of medicament for treating and improving lung PM2.5 deposition
  • Application of Chinese medicinal composition to preparation of medicament for treating and improving lung PM2.5 deposition

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0018] The preparation method of honey refining Chuanbei loquat extract:

[0019] Preparation of fritillaria fluid extract: take the prescription amount of Fritillaria fritillaria, and make Fritillaria fritillaria fluid extract with the same weight and volume as described; add 2-4 times the amount of 80% ethanol for the first time, soak for 1 hour, Then boil and reflux for extraction for 4 hours, force circulation once per hour, 15 minutes each time; add 2.5-5 times the amount of 70% ethanol for the second and third times, respectively boil and reflux for 4 hours, and force circulation once per hour, each time 15 minutes; release the medicinal solution and reclaim ethanol: the first time the liquid is discharged, the extraction solution with the volume of pure water of the same weight as the retention solution and the medicinal material is kept, and stored in another device, and the remaining extraction solution is combined with the second and third extraction solutions, and th...

Embodiment 1

[0021] Example 1 Milian Chuanbei Pipa Gao is used to prevent and improve lung function decline caused by PM2.5 deposition in the lungs

[0022] In the Guangzhou industrial area and traffic arteries, PM2.5 was sampled with a polytetrafluoroethylene filter membrane of a large flow sampler for 2 consecutive weeks, and the filter membrane loaded with particulate matter was immersed in deionized distilled water, and ultrasonically oscillated 3 times, each time for 40 minutes. Elute particulate matter. The oscillating solution was filtered through gauze, the filtrate was centrifuged at 4°C and 12,000 r / min for 30 minutes, the lower layer suspension was collected, lyophilized and vacuum-dried, and stored in a low-temperature refrigerator for later use. Make up the required concentration with normal saline, mix by ultrasonic oscillation for 15 minutes, store at 4°C, and oscillate before use to fully mix the particles.

[0023] Select SPF grade healthy Wistar male rats for use, 60, bo...

Embodiment 2

[0033] Example 2 Milian Chuanbei Pipa Gao is used to prevent and improve respiratory system immune damage caused by PM2.5 deposition in the lungs

[0034] In the Guangzhou industrial area and traffic arteries, PM2.5 was sampled with a polytetrafluoroethylene filter membrane of a large flow sampler for 2 consecutive weeks, and the filter membrane loaded with particulate matter was immersed in deionized distilled water, and ultrasonically oscillated 3 times, each time for 40 minutes. Elute particulate matter. The oscillating solution was filtered through gauze, the filtrate was centrifuged at 4°C and 12,000 r / min for 30 minutes, the lower layer suspension was collected, lyophilized and vacuum-dried, and stored in a low-temperature refrigerator for later use. Make up the required concentration with normal saline, mix by ultrasonic oscillation for 15 minutes, store at 4°C, and oscillate before use to fully mix the particles.

[0035] Select SPF grade healthy Wistar male rats for ...

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Abstract

The invention discloses an application of a Chinese medicinal composition to preparation of a medicament for treating and improving lung PM2.5 deposition. The Chinese medicinal composition comprises the following active ingredient raw materials in parts by weight: 10-30 parts of dried orange peel, 10-50 parts of platycodon root, 10-30 parts of typhonium flagelliforme, 50-150 parts of loquat leaf, 5-15 parts of common coltsfoot flower, 5-15 parts of unibract fritillary bulb, 10-30 parts of coastal glehnia root, 30 parts of Chinese magnoliavine fruit, 10-30 parts of apricot kernel or 0.1 percent (g / ml) apricot, 0-1 part of apricot kernel oil, 0.1-0.3 parts of peppermint camphor or 10-30 parts of peppermint. The Chinese medicinal composition provided by the invention can be used for remarkably preventing and improving lung function degradation and breathing system immune injury caused by lung PM2.5 deposition, and is middle-dose Chinese patent medicine which has definite curative effect and small toxic and side effects.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular, the invention relates to the application of a traditional Chinese medicine composition in the preparation of medicines for preventing and improving the deposition of PM2.5 in lungs. Background technique [0002] PM2.5 (particular matter 2.5) refers to fine particulate matter with aerodynamics ≤ 2.5 μm, which accounts for a considerable proportion of atmospheric particulate matter, about 70%. Premier Wen Jiabao of the State Council chaired an executive meeting of the State Council on February 29, 2012, and agreed to release the newly revised "Ambient Air Quality Standards". The scope of mandatory monitoring in various provinces and cities. [0003] Many medical experts have found clinically that the haze weather caused by fine particles is extremely harmful to human health. When the particle size is 10 μm, it will be blocked outside the human nose; when the particle size is 2.5 μ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8966A61P11/00A61K31/045
Inventor 魏大华卢其福黄喜梅刘薇随晶晶周立
Owner 广州白云山潘高寿药业股份有限公司
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