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Application of traditional Chinese medicine composition in preparation of medicament used for preventing and improving lung particulate matter 2.5 (PM2.5) deposition

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve the problems of preventing and improving PM2.5 that have not yet appeared, and achieve the effects of improving arterial blood, improving lung function decline, and less toxic and side effects

Active Publication Date: 2012-07-25
广州白云山潘高寿药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no drugs to prevent and improve PM2.5-induced lung deposition

Method used

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  • Application of traditional Chinese medicine composition in preparation of medicament used for preventing and improving lung particulate matter 2.5 (PM2.5) deposition
  • Application of traditional Chinese medicine composition in preparation of medicament used for preventing and improving lung particulate matter 2.5 (PM2.5) deposition
  • Application of traditional Chinese medicine composition in preparation of medicament used for preventing and improving lung particulate matter 2.5 (PM2.5) deposition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Improving the decline in lung function caused by PM2.5 deposition in the lungs

[0017] In the Guangzhou industrial area and traffic arteries, PM2.5 was sampled with a polytetrafluoroethylene filter membrane of a large flow sampler for 2 consecutive weeks, and the filter membrane loaded with particulate matter was immersed in deionized distilled water, and ultrasonically oscillated 3 times, each time for 40 minutes. Elute particulate matter. The oscillating solution was filtered through gauze, the filtrate was centrifuged at 4°C and 12,000 r / min for 30 minutes, the lower layer suspension was collected, lyophilized and vacuum-dried, and stored in a low-temperature refrigerator for later use. Make up the required concentration with normal saline, mix by ultrasonic oscillation for 15 minutes, store at 4°C, and oscillate before use to fully mix the particles.

[0018] Select SPF level healthy Wistar male rats for use, 60, body weight 220-250g, be divided into 5 ...

Embodiment 2

[0028] Example 2: Improving the respiratory system immune damage and oxidative damage caused by the deposition of PM2.5 in the lungs

[0029] In the Guangzhou industrial area and traffic arteries, PM2.5 was sampled with a polytetrafluoroethylene filter membrane of a large flow sampler for 2 consecutive weeks, and the filter membrane loaded with particulate matter was immersed in deionized distilled water, and ultrasonically oscillated 3 times, each time for 40 minutes. Elute particles. The oscillating solution was filtered through gauze, the filtrate was centrifuged at 4°C and 12,000 r / min for 30 minutes, the lower layer suspension was collected, lyophilized and vacuum-dried, and stored in a low-temperature refrigerator for later use. Make up the required concentration with normal saline, mix by ultrasonic oscillation for 15 minutes, store at 4°C, and oscillate before use to fully mix the particles.

[0030] Select male Kunming mice for use, 50, body weight 20-22g, be divided...

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Abstract

The invention discloses an application of a traditional Chinese medicine composition in preparation of a medicament used for preventing and improving lung particulate matter 2.5 (PM2.5) deposition. The active ingredients of the traditional Chinese medicine composition comprise the following raw materials in parts by weight: 5-8 parts of loguat leaf, 1-3 parts of Rhizoma Typhonii Flagelliformis, 0.4-3 parts of platycodon grandiflorum, 0-2 parts of liquorice, 1-4 parts of Szechuan-fritillary bulb, 0.1-1 part of animal bile, 0.01-0.05 part of menthol or 1-5 parts of mint, 0-3 parts of cynanchum glaucescens and 0-3 parts of radix stemonae. The traditional Chinese medicine composition disclosed by the invention can obviously improve diminished lung function and respiratory system immune injury caused by the lung PM2.5 deposition, and is a middle-dose Chinese patent medicine having precise effects and small toxic and side effects.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular, the invention relates to the application of a traditional Chinese medicine composition in the preparation of medicines for preventing and improving the deposition of PM2.5 in lungs. Background technique [0002] PM2.5 (particular matter 2.5) refers to aerodynamics. Fine particles ≤ 2.5 μm account for a considerable proportion of atmospheric particles, about 70%. Premier Wen Jiabao of the State Council chaired an executive meeting of the State Council on February 29, 2012, and agreed to release the newly revised "Ambient Air Quality Standards". The scope of mandatory monitoring in various provinces and cities. [0003] Many medical experts have found clinically that the haze weather caused by fine particles is extremely harmful to human health. When the particle size is ≥10 μm, it will be blocked outside the human nose; when the particle size is 2.5 μm-10 μm, it can enter the up...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61P11/00A61K35/413
Inventor 魏大华卢其福黄喜梅刘薇随晶晶周立
Owner 广州白云山潘高寿药业股份有限公司
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