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Platelet preserving agent

A technology of platelets and maintenance agents, which is applied in the field of blood collection tube additives, can solve the problems of platelet count accuracy, platelet original value, and unsatisfactory stability of the form, achieving remarkable implementation effects and ensuring accuracy

Active Publication Date: 2012-08-01
安徽信灵检验医学科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This single-component additive only considers the relationship between blood anticoagulation and morphological changes of red blood cells and the concentration of the additive, and it is equivalent to the biggest problem in blood cell analysis-protecting the accuracy of platelet counts and maintaining the stability of the original value of platelets. not ideal

Method used

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Examples

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Embodiment 1

[0029] [Example 1] The raw materials of the platelet maintenance agent according to the present invention are as follows (percentage by weight):

[0030]

[0031]

Embodiment 2

[0032] [Example 2] The raw materials of the platelet maintenance agent according to the present invention are as follows (percentage by weight):

[0033]

Embodiment 3

[0034] [Example 3] The preferred raw material ratio of the platelet maintenance agent according to the present invention is as follows (percentage by weight):

[0035]

[0036]

[0037] Since heparan, prostacyclin, urokinase, plasmin, and adrenomedullin are easily inactivated proteinaceous substances, when the platelet maintenance agent described in the present invention is prepared, the above five components are combined with other Raw material components are separated, added individually and mixed well. Taking the ratio of raw materials in Example 3 as an example, the preparation method of the platelet maintenance agent according to the present invention is as follows:

[0038] ① Step 1: Proportioning the main raw materials and applying ultrasonic waves;

[0039] Put the following raw materials by weight into an all-glass container, and perform ultrasonication for 20-25 minutes at a temperature of 28°C to 32°C through an ultrasonic cleaning machine with a working freq...

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Abstract

The invention relates to a platelet preserving agent, which has the following constituents (by weight percent): dipotassium EDTA: 10-14%, sodium citrate: 6-10%, Novocain:0.45-0.55%, Polyvinylpyrrolidone: 0.46-0.50%, polyethyleneglycol 6000: 0.48-0.52%, adenosine triphosphate: 0.03-0.07%, heparan: 0.005-0.015%, prostacyclin: 0.005-0.015%, urokinase: 0.01-0.03%, plasmin: 0.005-0.015%, adrenomedullin: 0.01-0.03%, hydroxyethyl cellulose sodium: 0.15-0.25%, JNSO-2000 long-acting antimicrobial agent: 0.05-0.15%, and water: the residual amount. The platelet preserving agent preparation method provided by the invention has the following steps in sequence: proportioning main raw materials and performing ultrasonic wave action, adding protein material liable to lose the activity and uniformly mixing, performing suction filtration and preparing. The platelet preserving agent provided by the invention enables platelets to maintain the stable state of individual distribution within 24 hours after leaving the body and have no statistical variation within 24 hours, thereby ensuring the accuracy in blood cell analysis. The platelet preserving agent preparation method provided by the invention has the remarkable implementation effect contrasted and verified by testing.

Description

technical field [0001] The invention relates to an additive for blood collection tubes, which is used to protect platelets in a single distribution form during blood collection of whole blood specimens in medical clinical testing, thereby improving the accuracy of clinical blood cell analysis. Background technique [0002] In existing medical clinical tests, when analyzing blood cells, most of the anticoagulant additives contained in the blood collection tubes used in the collection of whole blood samples are ethylenediaminetetraacetic acid dipotassium (EDTA-2K), Tripotassium ethylenediaminetetraacetic acid (EDTA-3K) or disodium ethylenediaminetetraacetic acid (EDTA-2Na), using its interaction with blood Ca ++ Complexing and anticoagulant properties. Therefore, EDTA potassium (sodium) salt is the preferred anticoagulant in blood cell analysis. According to the 1993 data of the International Committee for Standardization of Hematology (ICSH) (People's Military Medical Publi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/10
Inventor 王之侃
Owner 安徽信灵检验医学科技股份有限公司
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