Probiotics soft capsule and preparation method thereof

Abstract

The invention discloses a probiotics soft capsule, which comprises a content and a rubber skin for coating the content. 100 weight parts of content comprises the following components in part by weight: 0.001 to 45 part of probiotics, 10 to 40 parts of prebiotics, 35 to 60 parts of matrix oil, and 1 to 10 parts of stabilizer; and the viable content in the content is more than or equal to 106CFU / g. The rubber skin comprises the following components in part by weight: 13 to 79 parts of gel, 5 to 44 parts of plasticizer and 9 to 79 parts of water. The probiotics soft capsule can be orally taken or administrated through a cavity, has high-temperature resistance, can be stored for at least 24 months at room temperature, and has stable viable content; the probiotics soft capsule is transported at room temperature, so that the cost can be reduced; and the probiotics soft capsule is convenient to transport and carry. By the preparation method, the probiotics soft capsule has the advantages of simple operation, high controllability, high yield, stable quality, suitability for industrial production and the like.

Description

technical field [0001] The invention relates to a soft capsule and a preparation method thereof, in particular to a probiotic soft capsule and a preparation method thereof. Background technique [0002] Studies have shown that probiotics have important physiological functions on the body, including inhibiting the growth of intestinal pathogenic bacteria, reducing serum cholesterol levels, activating the immune system, and anti-cancer activities. With the increasing awareness of probiotics at home and abroad In-depth, more and more probiotic products have been promoted and applied in medical treatment, health care and nutrition. [0003] Probiotic products are mainly live bacteria preparations, most of which are obligate anaerobic bacteria, which are easily affected by external environmental factors such as temperature, oxygen, moisture, and acid-base, and are difficult to maintain activity. Probiotic products currently on the market, such as probiotic yogurt, probiotic milk...

AI Technical Summary

Problems solved by technology

[0003] Probiotic products are mainly live bacteria preparations, most of which are obligate anaerobic bacteria, which are easily affected by external environmental factors such as temperature, oxygen, moisture, and acid-base, and are difficult to maintain activity

Probiotic products currently on the market, such as probiotic yogurt, probiotic milk drinks and other dairy products, require low-temperature storage due to their high moisture content, large volume, easy contamination, and short shelf life.

Probiotics are also made into capsules, but the sealing of the capsules is poor, and they are easily affected by moisture, air, temperature, etc. during storage, so that the number of viable bacteria decreases rapidly

Chinese patent (publication number CN101357143A) discloses probiotic powder composition and its products. The probiotic powder used in the preparation of capsules is 50-80 mesh, and the powder is relatively thick, which is very easy to leak oil and block the liquid injection port during the preparation of soft capsules. , uneven loading and other problems, resulting in low yield of finished products and unstable product quality

[0004] To sum up: the prior art still has the following defects: (1) liquid probiotics have high water content, large volume, need low-temperature storage, and are inconvenient to carry and transport

(2) Probiotic hard capsules have poor sealing performance, short survival time of live bacteria, and rapid deactivation

(3) Probiotic soft capsules have high requirements on the production environment and process, and the existing soft capsule technology and production environment are not suitable for the industrialized production of probiotic soft capsules

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