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Method for detecting methamphetamine through surface enhanced Raman spectroscopy

A surface-enhanced Raman and methamphetamine technology is applied in Raman scattering, measuring devices, and material analysis through optical means. Convenience and the effect of lowering the detection limit

Inactive Publication Date: 2012-07-18
CHINA UNIVERSITY OF POLITICAL SCIENCE AND LAW
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to propose a method for detecting methamphetamine using surface-enhanced Raman spectroscopy in order to solve the problems of complex operation, slow analysis speed and low sensitivity in the prior art

Method used

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  • Method for detecting methamphetamine through surface enhanced Raman spectroscopy
  • Method for detecting methamphetamine through surface enhanced Raman spectroscopy
  • Method for detecting methamphetamine through surface enhanced Raman spectroscopy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The Raman spectrum of pure methamphetamine powder is as follows figure 1 shown. It can be seen from the figure that the Raman peak that appears in the range of 112-495cm-1 is the Raman peak of the "chair stretch" of the isopropyl group in the methamphetamine molecule; the Raman peak that appears in the range of 615-630cm-1 It is the Raman peak of the deformation of the δ ring in the methamphetamine molecule; the Raman peak that appears in the range of 748-850cm-1 is the Raman peak of the "chair extension" of the isopropyl group in the methamphetamine molecule; it appears at 990- The Raman peak in the range of 1100cm-1 is the Raman peak of the δ ring respiration in the methamphetamine molecule; the Raman peak in the range of 1015-1030cm-1 is the Raman peak of the in-plane deformation of the C-H bond in the methamphetamine molecule Man peak; the Raman peak that appears in the 1550-1630cm-1 scope is the Raman peak (double peak) that the benzene ring stretches in the metha...

Embodiment 2

[0037] Step 1, dissolving and diluting the ecstasy to form a test sample solution;

[0038] Step 2, preparation of silver sol

[0039] The preparation of silver sol, prepare silver sol by reduction of hydroxylamine hydrochloride, add sodium hydroxide solution to hydroxylamine hydrochloride solution and mix, then quickly add the mixture into silver nitrate solution, and stir rapidly during the addition process to make milky gray silver sol .

[0040] Centrifuge the above gold sol or silver sol at 1000r / min for 10 minutes with a centrifuge, discard the supernatant, and store the concentrated silver sol at room temperature in the dark for future use.

[0041] During the preparation process, the molar ratio of sodium hydroxide, hydroxylamine hydrochloride and silver nitrate is 1:0.6:0.011.

[0042] Step 3, take the test sample solution obtained in step 1 and the gold sol or silver sol obtained in step 2 and evenly mix it into a sample to be tested, and leave the sample to be tes...

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Abstract

The invention belongs to the technical field of drug detection, and particularly relates to a method for detecting methamphetamine through surface enhanced Raman spectroscopy, which includes the following steps: step I, pretreating a to-be-detected sample, so as to form sample solution; step II, preparing gold sol or silver sol; step III, uniformly mixing the test sample solution obtained through the step I and the gold sol or the silver sol obtained through the step II, so as to form the to-be-detected sample that is on standing; step IV, enabling the mixed to-be-detected sample obtained through the step III to be dripped on a slide and naturally evaporated for Raman spectrometry, thereby obtaining the SERS spectrogram of the gold sol and the to-be-detected sample or the SERS spectrogram of the silver sol and the to-be-detected sample; and step V, comparing the SERS spectrogram of the to-be-detected sample with the standard SERS spectrogram of the methamphetamine, so as to determine whether the sample contains the methamphetamine. The method for detecting the methamphetamine is simple to operate and quick to detect, has low sample consumption and detection cost, and can be widely applied to the detection field of the drug.

Description

technical field [0001] The invention relates to a method for detecting methamphetamine by using surface-enhanced Raman spectroscopy, and belongs to the technical field of drug detection. Background technique [0002] Methamphetamine, also known as methamphetamine, methamphetamine, is a pure white crystal, crystal clear, and looks like ice, commonly known as "ice". It is the main component of "ecstasy", has a strong central nervous system excitatory effect, has a strong mental dependence, and has serious harm to the human body. The abuse of methamphetamine drugs has brought great harm to people's lives and property. Therefore, in the work of forensic science, it is of great significance to realize the trace, sensitive, accurate, rapid and automatic detection of methamphetamine. [0003] At present, there are many detection methods at home and abroad. Chromatography has the advantages of high separation efficiency, fast analysis speed, good selectivity, and simultaneous anal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 郝红霞陈新明周红张中连园园刘晓培常靖常林张保生
Owner CHINA UNIVERSITY OF POLITICAL SCIENCE AND LAW
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