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Method for preparing alpha-linolenic acid molecular engram polymer material

A polymer material, molecular imprinting technology, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of separation and purification of α-linolenic acid and other problems that have not been seen, and achieve easy control of reaction conditions and resistance to harsh environments. Strong, low-cost effects

Inactive Publication Date: 2013-09-11
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

α-linolenic acid has only one functional group, the terminal carboxyl group, it is difficult to imprint α-linolenic acid with traditional functional monomers
At present, β-cyclodextrin has been used in the separation reports of theophylline, rutin, naringin and other substances, but there is no research and application on the separation and purification of α-linolenic acid

Method used

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Effect test

Embodiment 1

[0023] A method for preparing an α-linolenic acid molecularly imprinted polymer material, the steps are as follows:

[0024] (1) Preparation of pre-polymerization solution: Add 417.6mg (1.5mmol) template molecule α-linolenic acid and 5958.7mg (5.25mmol) functional monomer β-cyclodextrin into a 100mL flask, add 60mL dimethyl sulfoxide, Mix evenly, ultrasonically treat for 10 minutes, and carry out inclusion reaction under magnetic stirring for 24 hours to obtain a pre-polymerization solution of α-linolenic acid;

[0025] (2) Fixed crosslinking polymerization: Add 4541.4mg (27mmol) crosslinking agent hexamethylene diisocyanate to the α-linolenic acid prepolymerization solution in step (1), mix well, and keep the temperature at 60°C under magnetic stirring conditions Carry out the polymerization reaction for 24 hours, and finally obtain the polymerized particles of α-linolenic acid;

[0026] (3) Washing of polymer particles: cool the polymer particles of polymer α-linolenic acid...

Embodiment 2

[0035] A method for preparing an α-linolenic acid molecularly imprinted polymer material, the steps are as follows:

[0036] (1) Preparation of pre-polymerization solution: add 278.4mg (1.0mmol) template molecule α-linolenic acid and 3972.5mg (3.5mmol) functional monomer β-cyclodextrin to a 100mL flask, add 40mL distilled and dried Methyl sulfoxide solution, mixed evenly, ultrasonic treatment for 10 minutes, inclusion reaction under magnetic stirring for 24 hours, to obtain a pre-polymerization solution of α-linolenic acid;

[0037] (2) Fixed crosslinking polymerization: add 3134.9mg (18mmol) crosslinking agent toluene-2,4-diisocyanate to the α-linolenic acid prepolymerization solution in step (1), mix well, and 60 under magnetic stirring condition The polymerization reaction was carried out at a constant temperature of ℃ for 24 hours, and the polymerized particles of α-linolenic acid were finally obtained;

[0038] (3) Washing of polymer particles: cool the polymer particles...

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Abstract

The invention relates to a method for preparing an alpha-linolenic acid molecular engram polymer material. The method comprises the following steps of: adding alpha-linolenic acid and beta-cyclodextrin to a container, adding dimethyl sulfoxide, stirring for polymerizing to obtain an alpha-linolenic acid prepolymerization solution; adding hexamethylene diisocyanate or methylbenzene-2,4-diisocyanate and polymerizing to obtain alpha-linolenic acid polymerization grains; and cooling, washing, drying and grinding to obtain the alpha-linolenic acid molecular engram polymer material. According to the method for preparing the alpha-linolenic acid molecular engram polymer material, disclosed by the invention, alpha-linolenic acid is taken as template molecules, beta-cyclodextrin is taken as a functional monomer, contains polyhydroxy groups and more functional hydroxyl groups and has the characteristics of interior hydrophobicity and exterior hydrophilcity, and therefore beta-cyclodextrin can be fully polymerized with the alpha-linolenic acid to form a polymer containing the alpha-linolenic acid in a crosslinking manner; and after elution, the polymer containing the alpha-linolenic acid has engram holes consistent with those of the alpha-linolenic acid, thus the engram polymer material having higher specific selective absorption function to the alpha-linolenic acid is obtained.

Description

technical field [0001] The invention belongs to the technical field of functional polymer materials, in particular to a preparation method of α-linolenic acid molecularly imprinted polymer materials. Background technique [0002] α-linolenic acid is all-cis-9,12,15-octadecatrienoic acid, which is an omega-6 unsaturated fatty acid. It accounts for 10% of the total solid matter of the human brain, 25% and 50% of the human hippocampal cells, cranial nerves and retinitis phospholipids, and is an important nutrient that affects gene expression and nerve conduction. α-linolenic acid cannot be produced by itself in the human body, nor can it be artificially synthesized. It can only be supplemented by specific external foods. The content in general plants is very low. The amount obtained by ingesting these plant foods is far from meeting the needs of the human body. Therefore, enriching high-purity α-linolenic acid and adding it to food or medicine as a functional ingredient can me...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G18/67C08B37/16C08J9/26B01J20/26B01J20/30
Inventor 王昌禄陈新新李风娟王玉荣陈勉华李贞景
Owner TIANJIN UNIV OF SCI & TECH
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