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Method for preparing graphene oxide double-targeting medicine carrier material, and loaded medicine

A carrier material, graphene technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations with inactive ingredients, etc., can solve the problems of difficult large-scale preparation, high synthesis cost, complex structure, etc., and achieves strong targeting effect, Simple synthesis and efficient drug loading

Inactive Publication Date: 2012-07-11
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a preparation method of graphene oxide double-targeted drug carrier material to solve the problems of complex structure, high synthesis cost, low efficiency and difficulty in large-scale preparation of existing nano drug carriers

Method used

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  • Method for preparing graphene oxide double-targeting medicine carrier material, and loaded medicine
  • Method for preparing graphene oxide double-targeting medicine carrier material, and loaded medicine
  • Method for preparing graphene oxide double-targeting medicine carrier material, and loaded medicine

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specific Embodiment approach 1

[0012] Specific implementation mode one: this implementation mode comprises the following steps:

[0013] The first step: preparation of carboxymethylated graphene oxide; the detailed process is as follows: disperse 0.5-5.0 g of graphite oxide in 100-1000 mL of NaOH solution with a concentration of 0.2 mol / L, and ultrasonically disperse it for 10-60 minutes; then Add 2 to 20 g of chloroacetic acid to the above solution, stir for 2 to 10 hours; then centrifuge at a speed of 16000 r / min for 10 to 30 minutes, wash with water until the pH is 7 to 8, and finally vacuum dry to obtain carboxymethylated graphene oxide (GO -COOH); graphite oxide was prepared according to the Hummer method.

[0014] The second step: the preparation of graphene oxide-biological targeting molecular complex; the detailed process is as follows: disperse 80-800mgGO-COOH in 0.2-2L of 40mmol / L 2-(N-morpholine)ethanesulfonic acid (MES ) buffer solution, add 0.4~4g of N-hydroxysuccinamide (NHS) under stirring a...

specific Embodiment approach 2

[0018] Specific embodiment two: the difference between this embodiment and embodiment one is: the biological targeting molecule in the second step is folic acid, and what is obtained is graphene oxide folic acid complex (FA-GO); in the third step The obtained graphene oxide folic acid ferric oxide complex (FA-Fe 3 o 4 -GO).

specific Embodiment approach 3

[0019] Embodiment 3: This embodiment differs from Embodiment 1 in that: the biological targeting molecule is a polypeptide or antibody containing amino or hydroxyl groups in its molecular structure.

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Abstract

The invention relates to a method for preparing a graphene oxide double-targeting medicine carrier material, and a medicine loaded by the carrier material. The method is used for preparing the carrier material and the loaded medicine. The invention solves the problems that the conventional nano-medicine carrier has a complicated structure, is high in synthetic cost and low in efficiency, and cannot be massively prepared easily. The method for preparing the graphene oxide double-targeting medicine carrier material comprises the following steps of: preparing carboxymethylated graphene oxide; preparing a graphene oxide-biologically targeting molecule composite; and preparing the graphene oxide double-targeting medicine carrier material, wherein the loaded medicine is one or more of doxorubicin hydrochloride, paclitaxel, hydroxycamptothecine and daunomycin.

Description

technical field [0001] The invention relates to a method for preparing a graphene oxide double-targeting drug carrier material, and also relates to a drug loaded on the carrier material. Background technique [0002] As the thinnest new two-dimensional nanomaterial in the world, graphene's unique structure makes it have important application prospects in biomedicine, composite materials, sensors, energy and other fields, and has become a research hotspot in the field of nanotechnology in recent years. Since graphene has a single atomic layer structure, its theoretical specific surface area is as high as 2600m 2 / g, very suitable for use as a drug carrier. At the same time, both of its base surfaces can adsorb drugs, so it has an unmatched ultra-high drug loading rate of other nanomaterials. The graphene derivatives that are widely used in the biomedical field are mainly functionalized graphene oxide. Since graphene oxide contains a large number of oxygen-containing active...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K47/04A61K47/22A61K47/42A61P35/00
Inventor 胡桢黄玉东李翠云唐培毅李艳伟张丽
Owner HARBIN INST OF TECH
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