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Compound preparation containing ranitidine hydrochloride and troxipide and application thereof

A technology of ranitidine hydrochloride and compound preparation, which is applied in the field of drug compound preparations containing ranitidine hydrochloride and traxipide, can solve problems such as no reports, and achieve the effects of similar peak time and rapid absorption

Inactive Publication Date: 2012-07-11
PEKING UNIV FOUNDER GRP CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the drugs ranitidine hydrochloride and troxipide have been clinically used for many years and have very definite clinical therapeutic effects, there are no reports at home and abroad that the two drugs ranitidine hydrochloride and troxipide are made into compound preparations.

Method used

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  • Compound preparation containing ranitidine hydrochloride and troxipide and application thereof
  • Compound preparation containing ranitidine hydrochloride and troxipide and application thereof
  • Compound preparation containing ranitidine hydrochloride and troxipide and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Embodiment 1 common tablet formula (in every tablet)

[0068] Ranitidine Hydrochloride 50mg

[0069] Traxipide 50 mg

[0070] Microcrystalline Cellulose 200 mg

[0071] Starch 100mg

[0072] Lactose 75 mg

[0073] 8% Starch Slurry 200mg

[0074] Sodium Carboxymethyl Starch 20mg

[0075] Magnesium stearate 2mg

Embodiment 2

[0076] Embodiment 2 common tablet formula (in every tablet)

[0077] Ranitidine Hydrochloride 50mg

[0078] Traxipide 100mg

[0079] Microcrystalline Cellulose 200mg

[0080] Starch 75mg

[0081] Lactose 45mg

[0082] 70% ethanol 200mg

[0083] Sodium Carboxymethyl Starch 20 mg

[0084] Magnesium stearate 2mg

Embodiment 3

[0085] Embodiment 3 common tablet formula (in every tablet)

[0086] Ranitidine Hydrochloride 50mg

[0087] Traxipide 200mg

[0088] Microcrystalline Cellulose 150mg

[0089] Starch 75mg

[0090] 8% Starch Slurry 200mg

[0091] Polyvinylpolypyrrolidone 20mg

[0092] Magnesium stearate 2mg

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PUM

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Abstract

The invention provides a compound preparation containing ranitidine hydrochloride and troxipide and application thereof. The matching of ranitidine hydrochloride and troxipide according to weight ratio ranges from 6:1 to 1:6. Compared with the prior art, the compound preparation has the following advantages and active effects: ranitidine hydrochloride and troxipide have a pharmacology function and a coordinate effect, not only can treat stomach and intestine diseases including heartburn, gastropathy acid return and the like caused by gastric mucosal damage and too much gastric acid during acute-outbreak periods of acute gastritis and chronic gastritis, but also reinforce defense factors, improve recovery of ulcer diseases and metabolism of blood circulation of gastric mucosa at the ulcer parts, and enable gastric mucosa tissue components to be normalized. The effective dosage of ranitidine hydrochloride and troxipide in the compound preparation can be ensured, and the compound preparation further has the advantages of being effective in oral taking, similar in peak time and rapid in absorption.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a drug compound preparation containing ranitidine hydrochloride and troxipide. Background technique [0002] Ranitidine hydrochloride is an antagonist of histamine H2 receptors. Ranitidine hydrochloride has been widely used clinically since the 1980s. It has been included in the list of essential drugs in my country, and is included in the current Chinese Pharmacopoeia, as well as in the latest editions of the Pharmacopoeia published by the United States and the United Kingdom. At present, this drug is still one of the safest, most effective and most commonly used drugs for the treatment of peptic ulcer disease. In addition, its price is lower than that of similar drugs, making it the best choice for clinical treatment of peptic ulcer disease since its inception. One of the drugs. [0003] Traxipide is a new gastric mucosal protective agent. It has no effect on gastric acid...

Claims

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Application Information

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IPC IPC(8): A61K31/4462A61K31/341A61P1/04
Inventor 赵洪武唐凤
Owner PEKING UNIV FOUNDER GRP CO LTD
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