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Valnemulin gel microballoon and preparation method thereof

A technology of gel microspheres and warnimolin, which is applied in the direction of bulk transportation, active ingredients of esters, antibacterial drugs, etc., can solve the problems of poor stability, high irritation, and difficult storage, and achieve low production costs, The effect of simple preparation process and good market prospect

Inactive Publication Date: 2012-06-27
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Wonimulin has a bitter taste, strong hygroscopicity, strong irritation, relatively poor stability, and is not easy to store
There is also a certain palatability problem in the currently developed vonemulin products (premixes) abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) Weigh 1.6g CaCl 2 , 5g Vonimulin and 1g sodium alginate, spare;

[0019] (2) Use distilled water to mix CaCl 2 Dissolve and dilute to 100ml to get CaCl 2 Aqueous solution

[0020] (3) Mix vornemulin and sodium alginate, add 196ml of distilled water, stir and mix well to form a suspension;

[0021] (4) Drop the suspension prepared in step (3) into the CaCl of step (1) (the dropping rate is 100 drop / min) 2 After stirring and reacting for 10 minutes in an aqueous solution, the formed microspheres are filtered out, rinsed with distilled water, and dried to obtain Vonimulin gel microspheres. The particle size is 2.3μm, and the release in vitro can reach more than 20 days.

Embodiment 2

[0023] (1) Weigh 7.8g CaCl 2 , 2g Vonimulin and 6g sodium alginate, spare;

[0024] (2) Use distilled water to mix CaCl 2 Dissolve, dilute to 500ml, get CaCl 2 Aqueous solution

[0025] (3) Mix vornemulin and sodium alginate, add 500ml of distilled water, stir to mix well to form a suspension;

[0026] (4) Drop the suspension prepared in step (3) into the CaCl of step (1) (the dropping rate is 60drop / min) 2 After stirring and reacting for 24 hours in an aqueous solution, the formed microspheres are filtered out, rinsed with distilled water, and dried to obtain Vonimulin gel microspheres. The particle size is 18.3μm, and the release in vitro can reach more than 30 days.

Embodiment 3

[0028] (1) Weigh 4.7g CaCl 2 , 6g Vonimulin and 6g sodium alginate, spare;

[0029] (2) Use distilled water to mix CaCl 2 Dissolve, dilute to 200ml, get CaCl 2 Aqueous solution

[0030] (3) Mix vornemulin and sodium alginate, add 400ml of distilled water, and stir to mix well to form a suspension;

[0031] (4) Drop the suspension prepared in step (3) into the CaCl of step (1) (the dropping rate is 10drop / min) 2 After stirring and reacting for 48 hours in an aqueous solution, the formed microspheres are filtered out, rinsed with distilled water, and dried to obtain Vonimulin gel microspheres. The particle size is 23.7μm, and the release in vitro can reach more than 50 days.

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Abstract

The invention belongs to the technical field of veterinary medicine and particularly relates to a valnemulin gel microballon and a preparation method thereof. The grain diameter of the valnemulin gel microballoon is 1 mum to 50 mum and is composed of the following materials by mass: 1 part to 10 parts of valnemulin, 1 part to 10 parts of sodium alginate tech grade and 2 parts to 5 parts of calcium chloride. The valnemulin gel microballon and the preparation method thereof have the advantages of using the characteristic that when sodium alginate tech grade contacts calcium ions, gelation can happen instantly to embed the valnemulin, being simple in preparation processes, free of high temperature, organic solvent or other harmful compounds and low in production cost, meeting requirements of industrialization production and having good market prospects.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a warnemulin gel microsphere and a preparation method thereof. Background technique [0002] Valnemulin is a new generation of pleuromutilin (pleuromu.tilin) ​​semi-synthetic antibiotics. It belongs to diterpenes and is a similar drug to tiamulin. In 1984, Swiss Sandoz company Bemer et al took the lead in successfully synthesizing pleuromutilin. In 1999, the Swiss company Norvatis made it into a premix, trade name Econor, which is now on the market in many countries, mainly used to prevent and treat mycoplasma and intestinal spirochete infection in livestock and poultry. Due to its characteristics of safety, high efficiency, low toxicity, and resistance to drug resistance, vonemulin has been widely used in many countries. However, Wonimulin has a bitter taste, strong hygroscopicity, strong irritation, relatively poor stability, and is not easy to store. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/22A61K47/36A61P31/04
Inventor 胡帅樊楠柴保国
Owner HENAN SOAR VETERINARY PHARMA
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