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Method for preparing multifunctional nano microspheres (MPS) by utilizing drain nano particle self-assembly

A nano-microsphere, hydrophobic nano technology, applied in the field of nano-materials, to achieve the effect of strong novelty, simple and easy to operate

Active Publication Date: 2012-06-20
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no simple method for preparing nanoparticles with good water dispersibility by utilizing the interaction of thiols with metals.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Preparation of MPS microspheres: MPS microspheres were prepared by a one-step method. 300 μL of (3-mercapto)propyltrimethoxysilane (MPS) in isopropanol with a concentration of 12.5 mM was added to 12.5 mL of NH 4 The aqueous solution with an OH concentration of 0.075 mM was vigorously shaken at 2500 rpm for 2 minutes using an IKA MS3 micro-shaker. The obtained solution was left standing at normal temperature for 4 hours. The finally obtained product was washed twice with ethanol, and then the product was dispersed in 100 mL of toluene to obtain an MPS solution. The size of the finally obtained MPS microspheres is 869nm.

[0042] (2) Preparation of MPS-Au hybrid microspheres: 2500 μL of a toluene solution of gold particles with a diameter of 10 nm and a concentration of 0.45 mM, and then add the MPS microsphere solution prepared in step (1) to the above solution. Self-assembly occurs after mixing to obtain microspheres. The microspheres obtained after air drying w...

Embodiment 2

[0045] (1) Preparation of MPS microspheres: MPS microspheres were prepared by a one-step method, adding 250 μL of (3-mercapto)propyltrimethoxysilane (MPS) in isopropanol with a concentration of 12.5 mM to 10 mL of 0.625 mM NH 4 Vigorously shake the OH solution at 4000 rpm for 3 minutes using an IKA MS3 micro-shaker. The obtained solution was left standing at normal temperature for 3 hours. The finally obtained product was rinsed with propanol three times, and then dispersed into 100 mL of n-hexane to obtain an MPS solution. The size of the finally obtained MPS microspheres is 152nm.

[0046] (2) Preparation of MPS-ZrO 2 Hybrid microspheres: 2500 μL of ZrO with a diameter of 30 nm 2 The particle concentration is 3.75mM n-hexane solution, and then the MPS microsphere solution prepared in step (1) is added to the above solution. Self-assembly occurs after mixing to obtain microspheres. The microsphere size obtained after air drying was 563 nm. The microspheres can no longe...

Embodiment 3

[0049] (1) Preparation of MPS microspheres: MPS microspheres were prepared by a one-step method. 300 μL of (3-mercapto)propyltrimethoxysilane (MPS) in isopropanol at a concentration of 20 mM was added to 10 mL of NH 4 The aqueous solution with an OH concentration of 0.2 mM was vigorously shaken at 500 rpm for 20 minutes using an IKA MS3 micro-shaker. The obtained solution was left standing at normal temperature for 12 hours. The finally obtained product was washed with isopropanol three times, and then dispersed into 100 mL of n-heptane to obtain an MPS solution. The size of the finally obtained MPS microspheres is 641nm.

[0050] (2) Preparation of MPS-TiO 2 Hybrid microspheres: 2500 μL of TiO with a diameter of 1 nm 2 The particle concentration is 2.4mM n-heptane solution, and then the MPS microsphere solution prepared in step (1) is added to the above solution. Self-assembly occurs after mixing to obtain microspheres. The microsphere size obtained after air drying was ...

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Abstract

The invention relates to multifunctional nano microspheres (MPS) prepared by utilizing drain nano particle self-assembly, a preparation method thereof and dispersion thereof in water. The multifunctional nano MPS are prepared by (3-sulfydryl) propyltrimethoxyl silane, and the selected self-assembled drain particles are under 30nm. According to the invention, MPS are prepared, and the MPS and the drain particles produce self-assembly, so that the multifunctional nano MPS can be prepared, and further, the prepared multifunctional nano MPS are packaged by carbon dioxide so that the finally-obtained MPS can be uniformly dispersed in water solution. In the method disclosed by the invention, the drain nano particles are free from hydrophily modification before and during the self-assembly, and finally, the obtained nano material has better chemical / mechanical stability and water dispersibility so that the current requirements can be met.

Description

technical field [0001] The invention relates to the field of nanometer materials, in particular to a multifunctional nanometer microsphere prepared by self-assembly of hydrophobic nanoparticles, a preparation method thereof and dispersion in water. Background technique [0002] Multifunctional particles with micron or submicron size and two or more properties are ideal materials for technical applications, such as energy harvesting and conversion, multimodal imaging, detection, and diagnosis and treatment. For example, nanoparticle microspheres embedded with magnetic iron oxide and fluorescent quantum dots have been extensively studied as multimodal MRI contrast agents for optical detection and biological targeting. By strictly controlling the loaded quantum dots, the resulting composite particles possess dual functionalities of optical and magnetic separability. Replacing quantum dots with inert metals can prepare new materials with magnetic resonance and photothermal ther...

Claims

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Application Information

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IPC IPC(8): B01J13/02
Inventor 韩志超许杉杉
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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