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Application of ilexsaponin compound

A technology of hollywood saponins and compounds, applied in the field of medicine, can solve the problems of few reports on the pharmacological research of active ingredients and the like

Inactive Publication Date: 2012-06-20
刘国樵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Hairy Holly is a medicinal material with a wide range of uses, and the research on its pharmacological effects mainly focuses on the cardiovascular system, but all of them are extracts or preparations of Hairy Holly, and there are very few reports on the pharmacological research of its active ingredients

Method used

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  • Application of ilexsaponin compound
  • Application of ilexsaponin compound
  • Application of ilexsaponin compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1 Ilexin A, the preparation of Ilexin A1

[0031] Get 20Kg of Ilex rotunda medicinal material (Ilex rotunda Thunb.), extract with 95% ethanol, concentrate, concentrate is dispersed in silica gel and then placed in a continuous extraction separator, first use dichloromethane to heat and reflux for extraction, and solvent recovery to obtain Ilex rotunda saponin The crude product of element A is crystallized with ethanol to obtain piloseponin A, the content reaches 98.8% (measured by high-performance liquid chromatography), and the residue in the extractor is extracted by heating under reflux with ethyl acetate, and the solvent is recovered to obtain piloseponin The crude A1 product was crystallized with ethanol to obtain Ilexin A1 with a content of 98.2% (determined by high performance liquid chromatography).

Embodiment 2

[0032] The preparation of embodiment 2 Ilexin A tablet

[0033] Take 20g of hollygenin A, grind it into fine powder, add about 15g of 20% starch paste, mix, granulate with a 14-mesh sieve, dry at 100°C, granulate, add 2g of starch, 0.2g of magnesium stearate, and mix well , pressed into 100 pieces, that is. Each tablet weighs 0.25g and contains 200mg of hollygenin A.

Embodiment 3

[0034] The preparation of embodiment 3 Ilexin A1 capsules

[0035] Take 10g of Ilexin A and 10g of Ilexin A and grind it into fine powder, add about 15g of 20% starch paste, mix, granulate with a 14-mesh sieve, dry at 100°C, granulate, add 2g of starch, 0.2g of magnesium stearate , mix well, sieve, pack into capsules, make 100 capsules, and get ready. Each capsule weighs 0.25g and contains 1100mg of hollyside A and 100mg of hollynin A.

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Abstract

The invention relates to application of an ilexsaponin compound, in particular to application of a pentacyclic triterpenoid ilexsaponin compound to medicines for preparing cardiovascular diseases caused by myocardial ischemia and anoxia, and belongs to the field of medicines. The ilexsaponin compound is shown by a formula as the specification, wherein R is H or beta-D-glucose, and a structural formula of the beta-D-glucose is shown in the specification.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pentacyclic triterpenoid hollynin compound used to prepare medicines for diseases of the cardiovascular system. Background technique [0002] Ilex pubescens (Ilex pubescens Hook.et Am.), a traditional Chinese medicine, is the dried root of Ilex pubescens Hook.et Am., a plant commonly used in southern my country. It is widely distributed in various provinces in southern China, mainly produced in Guangxi and Guangdong provinces. It has the effects of activating blood circulation, reducing swelling and relieving pain, clearing away heat and detoxification, and is widely used clinically to treat coronary heart disease, angina pectoris, thromboangiitis obliterans, etc. [0003] Mao Dongqing and its preparations are mainly recorded in local drug standards, and were also included in the 77th edition of the Chinese Pharmacopoeia. At present, the preparations are mainly Mao Dongqing tablets, cap...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61K31/7024A61P9/10
Inventor 刘国樵
Owner 刘国樵
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