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Medicine composition and applications thereof

A composition and drug technology, applied in the field of preparing hypertension treatment drugs and heart failure treatment drugs, can solve the problems of poor patient compliance, large blood pressure fluctuations, and high treatment costs, and achieve improved quality of life, good treatment effects, and no adverse effects. Effects of side effects

Active Publication Date: 2012-06-06
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In order to overcome the common defects of high treatment cost, large side effects, and large blood pressure fluctuations in the process of lowering blood pressure in the existing hypertension drugs and the common defects of large side effects and poor patient compliance in the existing heart failure drugs, the present invention provides a The new pharmaceutical composition is used for the treatment of hypertension and heart failure. The pharmaceutical composition uses carvedilol or its pharmaceutically acceptable salt and fimasartan as the active ingredients of the medicine. It has comprehensive effects when used for the treatment of hypertension and has no side effects Smaller, the advantage of being able to achieve a smooth step-down

Method used

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  • Medicine composition and applications thereof
  • Medicine composition and applications thereof
  • Medicine composition and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 carvedilofimasartan compound tablet

[0027] Carvedilol 50g

[0028] Fimasartan 0.5g

[0029] Compressible starch 120g

[0030] Cyclodextrin 10g

[0031] Sodium carboxymethyl starch 10g

[0032] Magnesium stearate 0.6g

[0033] 5% PVP in absolute ethanol solution

[0034] Preparation process: first put carvedilol and cyclodextrin into a mortar, grind and mix evenly, then add carboxymethyl starch sodium, compressible starch and mix evenly, finally add Fimasartan and mix evenly, use 5% PVP The anhydrous ethanol solution is used as a binder to granulate, dried at 40°C, granulated, added with magnesium stearate, mixed evenly, and compressed into tablets.

Embodiment 2

[0035] The preparation of embodiment 2 carvedilofimasartan compound tablet

[0036] Carvedilol 0.6g

[0037] Fimasartan 600g

[0038] Compressible starch 130g

[0039] Cyclodextrin 10g

[0040] Sodium carboxymethyl starch 10g

[0041] Magnesium stearate 0.6g

[0042] 5% PVP in absolute ethanol solution

[0043] Preparation process: first put carvedilol and cyclodextrin into a mortar, grind and mix evenly, then add carboxymethyl starch sodium, compressible starch and mix evenly, finally add Fimasartan and mix evenly, use 5% PVP The anhydrous ethanol solution is used as a binder to granulate, dried at 40°C, granulated, added with magnesium stearate, mixed evenly, and compressed into tablets.

Embodiment 3

[0044] The preparation of embodiment 3 carvedilofimasartan compound tablet

[0045] Carvedilol 5g

[0046] Fimasartan 500g

[0047] Microcrystalline Cellulose 150g

[0048] β-cyclodextrin 10g

[0049] Sodium carboxymethyl starch 15g

[0050] Micronized silica gel 0.8g

[0051] Preparation process: first put carvedilol and β-cyclodextrin into a mortar and grind and mix evenly, then add sodium carboxymethyl starch, microcrystalline cellulose, micropowder silica gel and mix evenly, finally add Fimasartan and mix evenly , and the powder is directly compressed into tablets.

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Abstract

The invention discloses a medicine composition with active components of carvedilol and a medicinal salt thereof, and fimasartan. The invention also relates to an application of the medicine composition in treating hypertension and complications thereof, and an application of the medicine composition in treating congestive cardiac failure. In the medicine composition, a weight ratio of carvedilol and medicinal salt thereof to fimasartan is 1:0.01-1000. The components of the medicine composition are clear. When the medicine composition is used for treating hypertension and complications thereof, a substantial synergetic effect of the two medicine components is shown, and stable reduction of blood pressure can be realized; when the medicine composition is used for treating congestive cardiac failure, various cardiac indexes are substantially enhanced, a treatment effect is substantial, and a substantial synergetic effect of the two medicine components is shown.

Description

technical field [0001] The present invention relates to a kind of pharmaceutical composition and application thereof, specifically, relate to a kind of pharmaceutical composition with carvedilol or its pharmaceutically acceptable salt and fimasartan as active ingredients, and its preparation for the treatment of hypertension Use in medicines and medicines for heart failure treatment. Background technique [0002] Hypertension is the most common cardiovascular disease in the world, and it is also one of the largest epidemics. It often causes complications in the heart, brain, kidney and other organs, and seriously endangers human health. Early prevention and timely treatment are of great significance, and the research and development of drugs for the treatment of cardiovascular diseases has become one of the hot spots in the field of medical research. [0003] Hypertension is a syndrome with very complicated etiology and pathogenesis. Once diagnosed, it requires life-long me...

Claims

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Application Information

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IPC IPC(8): A61K31/513A61K31/403A61P9/12A61P9/04
Inventor 赵志全张帅
Owner LUNAN PHARMA GROUP CORPORATION
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