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Use of Silkie Melanin Extract in the Preparation of Medicines for Preventing and Treating Depression

A technology of melanin and extract, applied in the field of new use in medicine

Inactive Publication Date: 2014-10-29
贺毅 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no report on the use of silky melanin or its extract in the preparation of drugs for preventing and treating depression

Method used

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  • Use of Silkie Melanin Extract in the Preparation of Medicines for Preventing and Treating Depression
  • Use of Silkie Melanin Extract in the Preparation of Medicines for Preventing and Treating Depression
  • Use of Silkie Melanin Extract in the Preparation of Medicines for Preventing and Treating Depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1: Protective effect of black-bone chicken melanin extract on mouse tail suspension experimental depression model

[0050] 1. Grouping and screening of experimental animals

[0051]Before administration, test the basic test value of mouse tail suspension experiment, and carry out the tail suspension experiment as follows: use adhesive tape to stick the position of about 2 cm from the end of the mouse tail, hang the mouse upside down, fix it on a horizontal bar, and About 10 cm from the table. Partitions were used on both sides of the mouse to separate the sight of the animals to prevent mutual influence. There is no place for the mice to grasp, front, back, left, and right. After a period of time, the mice lose their activity due to disappointment. The immobility time of the last 4 minutes within 6 minutes was recorded. Eliminate the mice whose basic value exceeds the range of 65 to 130 seconds, and select 20 mice as qualified animals for the experiment, an...

Embodiment 2

[0063] Example 2: Protective effect of black-bone chicken melanin extract on mouse forced swimming test depression model

[0064] The forced swimming test was performed the next morning after the tail suspension test. The mice were put into a 2000ml beaker (20cm high, 14cm in diameter) with a water depth of 10cm, and the water temperature was kept at 25°C. When the mice were first placed in the water, they swam desperately and tried to climb up the beaker. After a while, the mice became less active in frustration. If the mouse remained afloat and breathed only through the nose, it indicated depression, and if the mouse swam, it indicated that it was not depressed. Observe for 6 minutes, and record the accumulated immobility time (the time spent floating on the water surface) within 4 minutes after that. After the test, the mice were dried with a towel and put back into the cage.

[0065] Table 3: Test values ​​of immobility time in the mouse forced swimming test (unit: se...

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Abstract

The invention discloses purpose of a black-bone silky fowl melanin extractive in preparation of a medicament for controlling depression. The black-bone silky fowl melanin extractive is used as an active component of the medicament. In the invention, the black-bone silky fowl melanin extractive can be prepared by a double enzyme hydrolysis method companied with alkali lye protein removal. According to the invention, the black-bone silky fowl melanin extractive has good anti-depression effect and can be used for preparation of the medicament for controlling depression.

Description

technical field [0001] The invention relates to the medical application of the black-bone chicken melanin extract, in particular to the new application of the silky chicken melanin extract in preparing medicines for preventing and treating depression. Background technique [0002] Depression is an affective disorder mental disease, mainly manifested as low mood, slow thinking and motor inhibition, often accompanied by sleep disorders, weakened digestive function, physical discomfort, self-blame and guilt, and even self-harm, suicidal ideation and Behavior. [0003] With the development of society and economy, the accelerated pace of life and the increase of life pressure, depression has become a common disease that endangers the physical and mental health of all human beings in modern society, and its incidence rate is increasing year by year. According to the latest statistical analysis of the World Health Organization (WTO), depression is one of the ten most serious disea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/12A61P25/24A61K35/57
Inventor 贺毅李博
Owner 贺毅
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