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Donkey-hide gelatin injection and preparation method thereof

A technology of injection and donkey-hide gelatin, which is applied in the field of traditional Chinese medicine injection and its preparation for the treatment of anemia symptoms, and can solve the problems of high enzyme separation cost, annual increase, and high preparation cost

Inactive Publication Date: 2012-05-16
李成林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main components of the injection prepared by this method are substances such as small molecule peptides, amino acids, etc., resulting in a higher gel point of the injection, and factors that affect quality such as annual increases during storage.
In addition, due to the use of enzymes, the requirements for the environment, namely pH, temperature, and humidity are very high. After the reaction is completed, the separation cost of the enzyme is relatively high, and the preparation cost is too high.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1. prepare the small volume injection of donkey-hide gelatin injection of the present invention

[0026] prescription:

[0027] Donkey-hide gelatin (based on N content) 5.0Kg

[0028] Polyurethane (adhesive) 10g

[0029] Sodium hydroxide 144g

[0030] Sodium chloride 1484g

[0031] Potassium chloride 44g

[0032] Calcium chloride 22.2g

[0033] 2% hydrochloric acid 20L

[0034] Water for injection 10L

[0035] 5ml / bottle, make 2000 bottles

[0036] Preparation: Put 5.0Kg donkey-hide gelatin in 10L water for injection, heat the solution to 80°C, keep the temperature until the relative viscosity of the solution reaches 2, stop heating and cool down. Use 20% NaOH solution to adjust the pH value of the degradation solution to 6, slowly add an appropriate amount of polyurethane and acetone (1:40) mixed solution, and keep stirring for 2.5 hours, use 20% NaOH solution to adjust the pH value of the reaction solution Stay in the 6.0 ra...

Embodiment 2

[0037] Embodiment 2. prepare the large-capacity sodium chloride injection of donkey-hide gelatin injection of the present invention

[0038] prescription:

[0039] Donkey-hide gelatin (based on N content) 9.0Kg

[0040] Polyurethane (adhesive) 20g

[0041] Sodium hydroxide 200g

[0042] Sodium chloride 1100g

[0043] Potassium chloride 60g

[0044] Calcium chloride 30g

[0045] 2% hydrochloric acid 5L

[0046] 200ml / bottle, make 1000 bottles

[0047] Preparation: Put 9.0Kg donkey-hide gelatin in 200L water for injection, heat the solution to 140°C, keep the temperature until the relative viscosity of the solution reaches 2, stop heating and cool down. Use 20% NaOH solution to adjust the pH value of the degradation solution to 7, slowly add an appropriate amount of polyurethane and acetone (1:5) mixed solution, and keep stirring for 2.5 hours, use 20% NaOH solution to adjust the pH value of the reaction solution Stay in the 6.2 range. Acetone wa...

Embodiment 3

[0047] Preparation: Put 9.0Kg donkey-hide gelatin in 200L water for injection, heat the solution to 140°C, keep the temperature until the relative viscosity of the solution reaches 2, stop heating and cool down. Use 20% NaOH solution to adjust the pH value of the degradation solution to 7, slowly add an appropriate amount of polyurethane and acetone (1:5) mixed solution, and keep stirring for 2.5 hours, use 20% NaOH solution to adjust the pH value of the reaction solution Stay in the 6.2 range. Acetone was removed by distillation under reduced pressure. Add water for injection to the remaining solution after distillation to 200L, mix well, add the prescribed amount of glucose, after dissolving, add hydrochloric acid solution to adjust the pH to 7.1-7.4. The relative viscosity of the solution should be in the range of 1.85-2.20. Sterilize, filter, fill, and get ready. Embodiment 3. prepare the large-capacity glucose injection of donkey-hide gelatin injection of the present i...

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Abstract

The invention relates to a donkey-hide gelatin injection which mainly comprises donkey-hide gelatin. The injection can be used for being prepared into any one common injection preparation, such as a high-capacity injection, a low-capacity injection and a lyophilized powder injection. The injection is prepared through the following steps: adding donkey-hide gelatin into injection water, heating, and cooling; regulating the pH with a NaOH solution, and adding an adhesive and acetone; removing acetone, and adding an electrolyte regulating substance; and regulating the pH, sterilizing, and encapsulating.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine injection with immune function and for treating ischemic symptoms, in particular to a traditional Chinese medicine injection for treating anemia symptoms and a preparation method thereof. Background technique: [0002] Donkey-hide gelatin is a traditional Chinese medicine decoction piece. It is made of donkey skin with hair removed, soaked for the second time, decocted in water several times, and concentrated with a slow fire. Its main chemical component is collagen. [0003] The Chinese Pharmacopoeia records its efficacy in stopping bleeding, enriching blood, nourishing yin and moistening dryness. In traditional Chinese medicine, donkey-hide gelatin is used for blood deficiency, chlorosis, dizziness, palpitations, yin deficiency, and various bleeding syndromes, and it is especially suitable for bleeding with yin deficiency and blood deficiency syndromes. [0004] Modern research proves that don...

Claims

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Application Information

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IPC IPC(8): A61K35/36A61K47/34A61K9/08A61K9/19A61P37/04A61P7/06A61P39/00
Inventor 李成林
Owner 李成林
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